Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.51 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20985324 | 1.00 | SYK (0.51) | SYKGRM5SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL20985300 | 0.89 | GRM5 (0.45) | SYKGRM5SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL30940519 | 0.89 | GRM5 (0.45) | SYKGRM5SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL30940521 | 0.87 | GRM5 (0.43) | SYKGRM5SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL20985236 | 0.87 | GRM5 (0.43) | SYKGRM5SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL20985220 | 0.84 | GRM5 (0.41) | SYKGRM5SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL20985261 | 0.84 | TYK2 (0.43) | GRM5L3MBTL1JAK2JAK1TYK2 | |
| SCHEMBL30940495 | 0.84 | GRM5 (0.41) | SYKGRM5SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL30940527 | 0.82 | GRM5 (0.44) | GRM5SMN1; SMN2ALDH1A1RAB9AHPGD | |
| SCHEMBL28408759 | 0.82 | GRM5 (0.44) | GRM5SMN1; SMN2ALDH1A1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111315737-B | Heteroaryl compounds substituted with sulfone pyridinylalkylamides | 百时美施贵宝公司 | 2024-06-18 | — | — | CN | disclosed |