Bufogenin

Bufogenin

SCHEMBL309405

C[C@]12CC[C@H](O)C[C@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](c3ccc(=O)oc3)C[C@H]3O[C@]132

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATP1A1 P05023 7/20 0.72
ATP1B1 P05026 7/20 0.72
ATP1A3 P13637 7/20 0.72
ATP1B2 P14415 7/20 0.72
ATP1A2 P50993 7/20 0.72
ATP1B3 P54709 7/20 0.72
FXYD2 P54710 7/20 0.72
ATP1A4 Q13733 7/20 0.72
CYP3A4 P08684 3/20 0.72
CYP3A5 P20815 2/20 0.72
AR P10275 1/20 0.72
ZFP91 Q96JP5 1/20 0.72
CYP3A7 P24462 1/20 0.52
STAT3 P40763 1/20 0.49
RAB9A P51151 3/20 0.46
NPC1 O15118 2/20 0.46
PAX8 Q06710 2/20 0.46
TP53 P04637 2/20 0.46
LMNA P02545 1/20 0.46
TSHR P16473 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bufogenin SCHEMBL309406 1.00 ATP1A1 (0.72) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
Bufogenin SCHEMBL16628192 1.00 ATP1A1 (0.72) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
Bufogenin SCHEMBL1652389 1.00 ATP1A1 (0.72) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
Bufogenin SCHEMBL4528502 1.00 ATP1A1 (0.72) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
Bufogenin SCHEMBL8168075 1.00 ATP1A1 (0.72) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
Bufogenin SCHEMBL21840080 0.99 ATP1A1 (0.70) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
Bufogenin SCHEMBL9098303 0.98 ATP1A1 (0.69) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
Bufogenin SCHEMBL10587453 0.97 ATP1A1 (0.68) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
Bufogenin SCHEMBL9752159 0.97 ATP1A1 (0.68) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
Bufogenin SCHEMBL17652299 0.97 ATP1A1 (0.68) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 8924 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122075504-A Application of bufogenin medicament in preparation of IHNV (infectious bursal disease virus) resisting product 2026-05-26 CN claimed
WO-2026102542-A1 ATPASE INHIBITORS FOR TREATMENT OF NEUROLOGICAL AND NON-NEUROLOGICAL DISORDERS HAPLO THERAPEUTICS INC. (CA) 2026-05-21 WO claimed
CN-122005549-A Application of indole alkali compound in preparation of medicine or skin care product for treating or preventing skin diseases 南京效真生物科技有限公司 2026-05-12 CN claimed
EP-4363043-B1 COMPOSITIONS FOR USE IN METHODS FOR INCREASING CANCER CELL SENSITIVITY TO ALTERNATING ELECTRIC FIELDS NOVOCURE GMBH (CH) 2026-04-22 EP claimed
US-12594421-B2 Compositions and methods for increasing cancer cell sensitivity to alternating electric fields NOVOCURE GMBH (CH) 2026-04-07 US claimed
US-20250339680-A1 COMPOSITIONS AND METHODS FOR INCREASING CANCER CELL SENSITIVITY TO ALTERNATING ELECTRIC FIELDS NOVOCURE GMBH (CH) 2025-11-06 US claimed
EP-4615506-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES Sahin, Fikret (TR) 2025-09-17 EP claimed
WO-2025120106-A1 METHODS FOR ISOLATING EMBRYONIC STEM CELLS FROM AN AVIAN EMBRYO CELLS SUPRÊME (FR) 2025-06-12 WO claimed
EP-4567102-A1 METHODS FOR ISOLATING EMBRYONIC STEM CELLS FROM AVIAN EMBRYONIC CELLS Suprême (FR) 2025-06-11 EP claimed
CN-120077031-A Prodrug kit for multitube concurrent chemotherapy 亚历克斯·祖内克 2025-05-30 CN claimed
EP-0016036-A4 ORGANOSILICON INFILTRATED REACTION SINTERED SILICON NITRIDE. US HEALTH (US) 1980-09-29 EP claimed
WO-1980001664-A1 METHOD AND DEVICE FOR GENTLE TREATMENT OF SPHERICAL BALLS PROJECTUS IND PRODUKTER AB 1980-08-21 WO claimed
EP-0012762-A1 SIGNAL TRANSLATOR WITH SQUELCH. BEI ELECTRONICS (US) 1980-07-09 EP claimed
WO-1980000740-A1 PIPE COUPLING DEVICE NOLEK SYSTEM AB 1980-04-17 WO claimed
EP-0009032-A1 Carrier having two wheels inclined towards one another. TODER ELLIS I 1980-03-19 EP claimed
WO-1980000021-A1 ORGANOSILICON INFILTRATED REACTION SINTERED SILICON NITRIDE US COMMERCE (US) 1980-01-10 WO claimed
WO-1979001062-A1 COMBINED COAL LIQUEFACTION AND GASIFICATION PROCESS GULF OIL CORP (US) 1979-12-13 WO claimed
WO-1979000906-A1 RECOVERY OF ELEMENTAL SULFUR AND METAL VALUES FROM TAILINGS FROM COPPER RECOVERY PROCESSES CYPRUS METALLURG PROCESS (US) 1979-11-15 WO claimed
WO-1979000728-A1 SIGNAL TRANSLATOR WITH SQUELCH BEI ELECTRONICS (US) 1979-10-04 WO claimed
WO-1979000662-A1 CANTED WHEELS CARRIER TODER E 1979-09-06 WO claimed