Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | CMA1 | P23946 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | CLPP | Q16740 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29234312 | 1.00 | SIGMAR1 (0.58) | SIGMAR1ALDH1A1KDM4EKMT2ACMA1 | |
| SCHEMBL29194556 | 0.89 | SIGMAR1 (0.47) | SIGMAR1ALDH1A1KDM4EKMT2ACMA1 | |
| SCHEMBL30245568 | 0.89 | SIGMAR1 (0.47) | SIGMAR1ALDH1A1KDM4EKMT2ACMA1 | |
| SCHEMBL30245633 | 0.87 | SIGMAR1 (0.47) | SIGMAR1ALDH1A1KDM4EKMT2ACMA1 | |
| SCHEMBL29194528 | 0.87 | SIGMAR1 (0.47) | SIGMAR1ALDH1A1KDM4EKMT2ACMA1 | |
| SCHEMBL30245484 | 0.85 | SIGMAR1 (0.44) | SIGMAR1ALDH1A1KDM4EKMT2ACMA1 | |
| SCHEMBL9871627 | 0.83 | SIGMAR1 (0.60) | SIGMAR1ALDH1A1KDM4EKMT2ACMA1 | |
| SCHEMBL25205014 | 0.83 | HSD17B10 (0.53) | SIGMAR1ALDH1A1KMT2ACMA1GAA | |
| SCHEMBL3847058 | 0.83 | SIGMAR1 (0.72) | SIGMAR1ALDH1A1KDM4EKMT2AGAA | |
| SCHEMBL29463795 | 0.83 | SIGMAR1 (0.72) | SIGMAR1ALDH1A1KDM4EKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117980302-A | Piperazine-based agonists of LFA-1 and VLA-4 | 德克萨斯心脏研究所 | 2024-05-03 | — | — | CN | disclosed |