SCHEMBL30946264

SCHEMBL30946264

COc1ccc2ncc(Oc3ccc(O[C@H](C)C(=O)O)cc3)nc2c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.61
HPGD P15428 3/20 0.61
NPSR1 Q6W5P4 2/20 0.61
CYP1A2 P05177 2/20 0.61
TP53 P04637 1/20 0.61
CYP3A4 P08684 1/20 0.61
ALOX15 P16050 1/20 0.61
NFKB1 P19838 1/20 0.61
HIF1A Q16665 1/20 0.61
GMNN O75496 1/20 0.61
LMNA P02545 1/20 0.61
MAPT P10636 1/20 0.61
APEX1 P27695 1/20 0.61
PMP22 Q01453 1/20 0.61
SMN1; SMN2 Q16637 1/20 0.61
HTT P42858 4/20 0.51
NPC1 O15118 2/20 0.51
RAB9A P51151 2/20 0.51
RXFP1 Q9HBX9 2/20 0.51
PLA2G10 O15496 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27259814 1.00 ALDH1A1 (0.61) ALDH1A1HPGDNPSR1CYP1A2TP53
SCHEMBL27259769 0.88 ALDH1A1 (0.55) ALDH1A1HPGDNPSR1CYP1A2TP53
SCHEMBL30946251 0.88 ALDH1A1 (0.55) ALDH1A1HPGDNPSR1CYP1A2TP53
SCHEMBL27259736 0.88 ALDH1A1 (0.61) ALDH1A1HPGDNPSR1CYP1A2TP53
SCHEMBL30946275 0.88 ALDH1A1 (0.61) ALDH1A1HPGDNPSR1CYP1A2TP53
R(+)Xk469 SCHEMBL31494114 0.87 ALDH1A1 (0.80) ALDH1A1HPGDNPSR1CYP1A2TP53
R(+)Xk469 SCHEMBL1958606 0.87 ALDH1A1 (0.80) ALDH1A1HPGDNPSR1CYP1A2TP53
SCHEMBL29413788 0.87 ALDH1A1 (0.60) ALDH1A1HPGDNPSR1CYP1A2TP53
R(+)Xk469 SCHEMBL10261981 0.87 ALDH1A1 (0.80) ALDH1A1HPGDNPSR1CYP1A2TP53
SCHEMBL30735548 0.87 ALDH1A1 (0.60) ALDH1A1HPGDNPSR1CYP1A2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4583874-A1 MULTITARGET NUCLEAR RECEPTOR LIGANDS BASED ON 2-(4-(QUINOLIN-2-YLOXY)PHENOXY)PROPANOIC ACID AND 2-(4-(QUINOXALIN-2-YLOXY)PHENOXY)PROPANOIC ACID FOR THE TREATMENT OF METABOLIC AND LIVER DISEASES CHARLES UNIVERSITY, FACULTY OF PHARMACY IN HRADEC KRALOVE (CZ) 2025-07-16 EP disclosed
WO-2024132001-A1 MULTITARGET NUCLEAR RECEPTOR LIGANDS BASED ON 2-(4-(QUINOLIN-2-YLOXY)PHENOXY)PROPANOIC ACID AND 2-(4-(QUINOXALIN-2-YLOXY)PHENOXY)PROPANOIC ACID FOR THE TREATMENT OF METABOLIC AND LIVER DISEASES CHARLES UNIVERSITY, FACULTY OF PHARMACY IN HRADEC KRALOVE (CZ) 2024-06-27 WO disclosed