Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 3/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL527804 | 0.98 | TSHR (0.47) | TSHRTDP1MAPTCACNA1BAPBA1 | |
| SCHEMBL8672977 | 0.95 | TSHR (0.46) | TSHRTDP1MAPTCACNA1BAPBA1 | |
| Malonic Acid SCHEMBL31256740 | 0.95 | TSHR (0.46) | TSHRTDP1MAPTCACNA1BAPBA1 | |
| Butane SCHEMBL3817891 | 0.90 | TSHR (0.55) | TSHRTDP1MAPTCACNA1BAPBA1 | |
| SCHEMBL8865453 | 0.88 | TSHR (0.50) | TSHRTDP1MAPTCACNA1BAPBA1 | |
| SCHEMBL7690120 | 0.87 | TSHR (0.43) | TSHRTDP1MAPTCACNA1BAPBA1 | |
| SCHEMBL57069 | 0.85 | TSHR (0.52) | TSHRTDP1MAPTCACNA1BAPBA1 | |
| Acetoacetic Acid SCHEMBL1318189 | 0.84 | TSHR (0.44) | TSHRTDP1MAPTCACNA1BAPBA1 | |
| Lithium SCHEMBL31366079 | 0.83 | TSHR (0.50) | TSHRTDP1MAPTCACNA1BAPBA1 | |
| SCHEMBL8521347 | 0.83 | TDP1 (0.36) | TSHRTDP1MAPTCACNA1BAPBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093406-B2 | Cyclic sulfones with aminobenzyl substitution useful as BACE inhibitors | NOVARTIS AG (CH) | 2012-01-10 | — | — | US | disclosed |
| EP-2303857-A1 | CYCLIC SULFONES WITH AMINOBENZYL SUBSTITUTION USEFUL AS BACE INHIBITORS | Novartis AG (CH) | 2011-04-06 | — | — | EP | disclosed |
| EP-2190833-A1 | AMINOBENZYL-SUBSTITUTED CYCLIC SULFONES USEFUL AS BACE INHIBITORS | Novartis Ag (CH) | 2010-06-02 | — | — | EP | disclosed |
| US-20100056490-A1 | Cyclic sulfones with aminobenzyl substitution useful as BACE inhibitors | NOVARTIS AG (CH) | 2010-03-04 | — | — | US | disclosed |
| WO-2010003976-A1 | CYCLIC SULFONES WITH AMINOBENZYL SUBSTITUTION USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2010-01-14 | — | — | WO | disclosed |
| WO-2009024615-A1 | AMINOBENZYL-SUBSTITUTED CYCLIC SULFONES USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2009-02-26 | — | — | WO | disclosed |
| US-20090054427-A1 | AMINOBENZYL-SUBSTITUTED CYCLIC SULFONES USEFUL AS BACE INHIBITORS | BRIARD EMMANUELLE | 2009-02-26 | — | — | US | disclosed |
| JP-2008214192-A | CRYSTAL OF MAGNESIUM SALT OF MONOALLYL MALONATE | SHIONOGI & CO LTD | 2008-09-18 | — | — | JP | disclosed |
| US-5672701-A | 4-substituted alkyl carbapenem antibiotics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-09-30 | — | — | US | disclosed |
| CN-1030918-C | 4-substituted alkyl carbapenem antibiotics | BRISTOL MYERS SQUIBB CO (US) | 1996-02-07 | — | — | CN | disclosed |
| US-5140030-A | Azido intermediates; carbapenicillin antibiotics | MERCK (US) | 1992-08-18 | — | — | US | disclosed |
| EP-0433759-A1 | 4-Substituted alkyl carbapenem antibiotics | Bristol-Myers Squibb Company (US) | 1991-06-26 | — | — | EP | disclosed |
| US-4892869-A | ANTIBIOTICS | MERCK & CO., INC. (US) | 1990-01-09 | — | — | US | disclosed |
| US-4833167-A | ANTIBIOTICS, BACTERICIDES | MERCK & CO., INC. (US) | 1989-05-23 | — | — | US | disclosed |
| US-4783453-A | 2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids | MERCK & CO., INC. (US) | 1988-11-08 | — | — | US | disclosed |
| US-4782051-A | 2-aza-substituted 1-carbadethiapen-2-em-3 carboxylic acids | MERCK & CO., INC. (US) | 1988-11-01 | — | — | US | disclosed |
| EP-0208889-A1 | 2-Aza-substituted 1-carbadethiapen-2-EM-3-carboxylic acids | MERCK & CO. INC. (US) | 1987-01-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054427-A1 | AMINOBENZYL-SUBSTITUTED CYCLIC SULFONES USEFUL AS BACE INHIBITORS | BACE2, BACE1, APP | TSHR 4858/4885TDP1 1688/4885MAPT 49/4885 |
| US-20100056490-A1 | Cyclic sulfones with aminobenzyl substitution useful as BACE inhibitors | BACE2, BACE1, APP | TSHR 4855/4885TDP1 1554/4885MAPT 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.