Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 9/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.33 |
| ▸ | CDK9 | P50750 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.32 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.32 |
| ▸ | RPS17 | P08708 | 1/20 | 0.32 |
| ▸ | RPSA | P08865 | 1/20 | 0.32 |
| ▸ | RPS2 | P15880 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24929883 | 1.00 | HPGD (0.48) | HPGDSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL30361438 | 0.87 | HPGD (0.46) | HPGDSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL30947687 | 0.87 | HPGD (0.46) | HPGDSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL29259564 | 0.87 | HPGD (0.46) | HPGDSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL29259578 | 0.87 | HPGD (0.46) | HPGDSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL24463691 | 0.83 | HPGD (0.53) | HPGDSMN1; SMN2ALDH1A1RXRAVNN1 | |
| SCHEMBL30361471 | 0.82 | HPGD (0.52) | HPGDSMN1; SMN2MEN1KMT2ARXRA | |
| SCHEMBL24929596 | 0.82 | HPGD (0.57) | HPGDALDH1A1RXRAVNN1LRRK2 | |
| SCHEMBL31038239 | 0.82 | HPGD (0.49) | HPGDSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL30201327 | 0.82 | HPGD (0.49) | HPGDSMN1; SMN2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118201926-A | Bicyclic PGDH inhibitors and methods of making and using the same | 埃皮里姆生物股份有限公司 | 2024-06-14 | — | — | CN | disclosed |