Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.57 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | ACACA | Q13085 | 1/20 | 0.38 |
| ▸ | VNN1 | O95497 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24463691 | 0.88 | HPGD (0.53) | HPGDLRRK2RXRAVNN1ALDH1A1 | |
| SCHEMBL30361471 | 0.87 | HPGD (0.52) | HPGDLRRK2RXRAVNN1ADORA2A | |
| SCHEMBL24929267 | 0.85 | HPGD (0.50) | HPGDLRRK2ALDH1A1HTTIDO1 | |
| SCHEMBL24929885 | 0.83 | HPGD (0.51) | HPGDADORA2A | |
| SCHEMBL30947679 | 0.82 | HPGD (0.48) | HPGDLRRK2RXRAVNN1ALDH1A1 | |
| SCHEMBL24929883 | 0.82 | HPGD (0.48) | HPGDLRRK2RXRAVNN1ALDH1A1 | |
| SCHEMBL24929598 | 0.82 | HPGD (0.56) | HPGDLRRK2ACACBACACAALDH1A1 | |
| SCHEMBL30947683 | 0.81 | HPGD (0.50) | HPGDLRRK2RXRAVNN1ADORA2A | |
| SCHEMBL24928924 | 0.80 | HPGD (0.52) | HPGDLRRK2RXRAVNN1ADORA2A | |
| SCHEMBL30361451 | 0.80 | HPGD (0.52) | HPGDLRRK2RXRAVNN1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4377314-A1 | BICYCLIC PGDH INHIBITORS AND METHODS OF MAKING AND USING | Epirium Bio Inc. (US) | 2024-06-05 | — | — | EP | disclosed |
| WO-2023009618-A1 | BICYCLIC PGDH INHIBITORS AND METHODS OF MAKING AND USING | EPIRIUM BIO, INC. (US) | 2023-02-02 | — | — | WO | disclosed |
| WO-2023009618-A1 | BICYCLIC PGDH INHIBITORS AND METHODS OF MAKING AND USING | EPIRIUM BIO, INC. (US) | 2023-02-02 | — | — | WO | disclosed |