Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | MARK3 | P27448 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.41 |
| ▸ | MGMT | P16455 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | GDA | Q9Y2T3 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27638755 | 0.73 | DPP4 (0.39) | PDPK1CDK2CHEK1AURKACHEK2 | |
| SCHEMBL17165346 | 0.72 | PIK3CA (0.44) | MGMTHSD17B10DPP4GDAPIK3CA | |
| SCHEMBL31258318 | 0.72 | PIK3CA (0.44) | MGMTHSD17B10DPP4GDAPIK3CA | |
| SCHEMBL31360537 | 0.69 | CYP1A2 (0.35) | PDPK1CDK2CHEK1AURKACHEK2 | |
| SCHEMBL29002285 | 0.69 | CYP1A2 (0.35) | PDPK1CDK2CHEK1AURKACHEK2 | |
| SCHEMBL28004915 | 0.69 | EGFR (0.48) | PDPK1CDK2CHEK1AURKACHEK2 | |
| SCHEMBL29375916 | 0.69 | PDPK1 (0.66) | PDPK1CDK2LRRK2DPP4GDA | |
| SCHEMBL1898183 | 0.69 | GDA (0.41) | PDPK1CDK2MGMTHSD17B10CYP1A2 | |
| SCHEMBL19780 | 0.69 | PDPK1 (0.66) | PDPK1CDK2LRRK2DPP4GDA | |
| SCHEMBL29366073 | 0.68 | PDPK1 (0.44) | PDPK1CDK2CHEK1AURKACHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118251494-A | Compositions and methods for modulating KRAS expression | 美国微哲默理有限责任公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-118176299-A | Compositions and methods for modulating NLRP3 or NLRP1 expression | 美国微哲默理有限责任公司 | 2024-06-11 | — | — | CN | disclosed |