Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.69 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3107713 | 1.00 | TMIGD3 (0.69) | TMIGD3ADORA1CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL3105643 | 1.00 | TMIGD3 (0.69) | TMIGD3ADORA1CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL3100806 | 1.00 | TMIGD3 (0.69) | TMIGD3ADORA1CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL3405853 | 0.99 | TMIGD3 (0.71) | TMIGD3ADORA1CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL3100117 | 0.88 | TMIGD3 (0.77) | TMIGD3ADORA1CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL16975047 | 0.83 | CYP1A2 (0.57) | TMIGD3ADORA1CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL3108511 | 0.82 | TMIGD3 (1.00) | TMIGD3ADORA1CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL16975060 | 0.82 | CYP1A2 (0.59) | TMIGD3ADORA1CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL3108090 | 0.81 | CYP1A2 (0.55) | TMIGD3ADORA1CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL19687613 | 0.79 | TMIGD3 (0.67) | TMIGD3ADORA1CYP1A2CYP2C9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9181269-B2 | Enantiomers of fluconazole analogues containing thieno-[2,-3-D]pyrimidin-4(3H)-one moiety as antifungal agents | FDC LIMITED (IN) | 2015-11-10 | — | — | US | disclosed |
| US-20140011818-A1 | ENANTIOMERS OF FLUCONAZOLE ANALOGUES CONTAINING THIENO-[2,-3-D]PYRIMIDIN-4(3H)-ONE MOIETY AS ANTIFUNGAL AGENTS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-01-09 | — | — | US | disclosed |
| US-8324227-B2 | Thieno[2,3-D]-pyrimidin-4(3H)-one compounds with antifungal properties and process thereof | FDC LIMITED (US) | 2012-12-04 | — | — | US | disclosed |
| EP-2257555-A1 | THIENO[2,3-D]-PYRIMIDINE-4(3H)-ONE COMPOUNDS WITH ANTIFUNGAL PROPERTIES AND PROCESS THEREOF | National Chemical Laboratory (IN) | 2010-12-08 | — | — | EP | disclosed |
| US-20100273815-A1 | THIENO[2,3-D]-PYRIMIDIN-4(3H)-ONE COMPOUNDS WITH ANTIFUNGAL PROPERTIES AND PROCESS THEREOF | FDC LIMITED | 2010-10-28 | — | — | US | disclosed |
| WO-2009109983-A1 | THIENO[2,3-D]-PYRIMIDINE-4(3H)-ONE COMPOUNDS WITH ANTIFUNGAL PROPERTIES AND PROCESS THEREOF | NATIONAL CHEMICAL LABORATORY (IN) | 2009-09-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273815-A1 | THIENO[2,3-D]-PYRIMIDIN-4(3H)-ONE COMPOUNDS WITH ANTIFUNGAL PROPERTIES AND PROCESS THEREOF | ERG28, DPM1, CYP51A1 | TMIGD3 1939/4885ADORA1 1458/4885CYP1A2 65/4885 |
| US-20140011818-A1 | ENANTIOMERS OF FLUCONAZOLE ANALOGUES CONTAINING THIENO-[2,-3-D]PYRIMIDIN-4(3H)-ONE MOIETY AS ANTIFUNGAL AGENTS | ERG28, CYP51A1, CYP4B1 | TMIGD3 2664/4885ADORA1 301/4885CYP1A2 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.