Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.65 |
| ▸ | GAA | P10253 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | CASP1 | P29466 | 2/20 | 0.45 |
| ▸ | CASP7 | P55210 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23625932 | 1.00 | KDM4E (0.65) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL30952894 | 1.00 | KDM4E (0.65) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL30952930 | 0.91 | KDM4E (0.79) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL23625923 | 0.91 | KDM4E (0.79) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL30952885 | 0.91 | KDM4E (0.79) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL31324803 | 0.89 | KDM4E (0.81) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL5666716 | 0.89 | KDM4E (0.81) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL24824319 | 0.88 | KDM4E (0.70) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL24961374 | 0.87 | KDM4E (0.73) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL30041634 | 0.87 | KDM4E (0.73) | KDM4EALDH1A1GAAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113767090-B | Tricyclic compound, preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2024-05-28 | — | — | CN | disclosed |