Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Surinabant. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 known ✓ | P21554 | 12/20 | 1.00 |
| ▸ | CNR2 | P34972 | 8/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.69 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.69 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.69 |
| ▸ | MLNR | O43193 | 1/20 | 0.69 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.69 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.69 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.69 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.69 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.69 |
| ▸ | DRD1 | P21728 | 1/20 | 0.69 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.69 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.69 |
| ▸ | HRH2 | P25021 | 1/20 | 0.69 |
| ▸ | HTR2A | P28223 | 1/20 | 0.69 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.69 |
| ▸ | CCKAR | P32238 | 1/20 | 0.69 |
| ▸ | CCKBR | P32239 | 1/20 | 0.69 |
| ▸ | MC4R | P32245 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Surinabant SCHEMBL675894 | 1.00 | CNR1 (1.00) | CNR1CNR2CYP2C9GPR55ABCC4 | |
| SCHEMBL5160340 | 0.94 | CNR1 (0.90) | CNR1CNR2CYP2C9GPR55ABCC4 | |
| Surinabant SCHEMBL4002662 | 0.94 | CNR1 (0.89) | CNR1CNR2CYP2C9GPR55ABCC4 | |
| SCHEMBL12053804 | 0.92 | CNR1 (0.85) | CNR1CNR2CYP2C9GPR55ABCC4 | |
| SCHEMBL10138900 | 0.92 | CNR1 (0.85) | CNR1CNR2CYP2C9GPR55ABCC4 | |
| SCHEMBL12053658 | 0.91 | CNR1 (0.84) | CNR1CNR2CYP2C9GPR55ABCC4 | |
| Surinabant SCHEMBL4002413 | 0.91 | CNR1 (0.84) | CNR1CNR2CYP2C9GPR55ABCC4 | |
| SCHEMBL8226008 | 0.91 | CNR1 (0.84) | CNR1CNR2CYP2C9GPR55ABCC4 | |
| SCHEMBL6162630 | 0.91 | CNR1 (0.82) | CNR1CNR2CYP2C9GPR55ABCC4 | |
| SCHEMBL12053648 | 0.91 | CNR1 (0.82) | CNR1CNR2CYP2C9GPR55ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4618987-A1 | METHODS FOR PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE BY MODULATING OR INHIBITING CANNABINOID RECEPTOR 1 | Joyboy The Igwe L.L.C. (US) | 2025-09-24 | — | — | EP | claimed |
| WO-2024129891-A1 | METHODS FOR PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE BY MODULATING OR INHIBITING CANNABINOID RECEPTOR 1 | JOYBOY THE IGWE L.L.C. (US) | 2024-06-20 | — | — | WO | claimed |
| EP-4618987-A1 | METHODS FOR PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE BY MODULATING OR INHIBITING CANNABINOID RECEPTOR 1 | Joyboy The Igwe L.L.C. (US) | 2025-09-24 | — | — | EP | disclosed |
| WO-2024129891-A1 | METHODS FOR PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE BY MODULATING OR INHIBITING CANNABINOID RECEPTOR 1 | JOYBOY THE IGWE L.L.C. (US) | 2024-06-20 | — | — | WO | disclosed |