SCHEMBL6162630

SCHEMBL6162630

CCc1c(C(=O)NN2CCC(O)CC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Br)cc1

nearest known ligand 0.82

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 10/20 0.82
CNR2 P34972 6/20 0.82
KCNH2 Q12809 2/20 0.58
ABCC4 O15439 1/20 0.56
MLNR O43193 1/20 0.56
ABCB11 O95342 1/20 0.56
CHRM2 P08172 1/20 0.56
ADORA3 P0DMS8 1/20 0.56
CYP2C9 P11712 1/20 0.56
ADRA2B P18089 1/20 0.56
ADRA2C P18825 1/20 0.56
DRD1 P21728 1/20 0.56
TBXA2R P21731 1/20 0.56
SLC6A2 P23975 1/20 0.56
HRH2 P25021 1/20 0.56
HTR2A P28223 1/20 0.56
AGTR1 P30556 1/20 0.56
CCKAR P32238 1/20 0.56
CCKBR P32239 1/20 0.56
MC4R P32245 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Surinabant SCHEMBL30953789 0.91 CNR1 (1.00) CNR1CNR2KCNH2ABCC4MLNR
Surinabant SCHEMBL675894 0.91 CNR1 (1.00) CNR1CNR2KCNH2ABCC4MLNR
SCHEMBL16136753 0.88 CNR1 (0.82) CNR1CNR2KCNH2ABCC4MLNR
SCHEMBL16136752 0.88 CNR1 (0.82) CNR1CNR2KCNH2ABCC4MLNR
SCHEMBL17645111 0.88 CNR1 (0.73) CNR1CNR2KCNH2ABCC4MLNR
SCHEMBL14510318 0.86 CNR1 (0.83) CNR1CNR2
SCHEMBL5923865 0.86 CNR1 (0.76) CNR1CNR2KCNH2
SCHEMBL4000445 0.86 CNR1 (0.73) CNR1CNR2KCNH2
Surinabant SCHEMBL4002413 0.85 CNR1 (0.84) CNR1CNR2KCNH2ABCC4MLNR
Surinabant SCHEMBL14338886 0.85 CNR1 (0.78) CNR1CNR2KCNH2ABCC4MLNR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1583758-A1 DERIVATIVE OF 5-(4-BROMOPHENYL)-1-(2,4-DICHLOROPHENLY)-4-ETHYL-N-(PIPERIDINE-1-YL)-1H-PYRAZOL-3-CARBOXAMIDE, THE PREPARATION AND THERAPEUTIC USE THEREOF Sanofi-Aventis (FR) 2005-10-12 EP disclosed
WO-2004058744-A1 DERIVATIVE OF 5-(4-BROMOPHENYL)-1-(2,4-DICHLOROPHENLY)-4-ETHYL-N-(PIPERIDINE-1-YL)-1H-PYRAZOL-3-CARBOXAMIDE, THE PREPARATION AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2004-07-15 WO disclosed