SCHEMBL30953869

SCHEMBL30953869

O=C1CC2(CCOC2)Oc2cc(C(F)(F)F)ccc21

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAF1 P04049 3/20 0.41
KCNH2 Q12809 1/20 0.41
ALDH1A1 P00352 2/20 0.38
KDM4E B2RXH2 3/20 0.37
ATM Q13315 3/20 0.37
HTT P42858 2/20 0.36
HDAC3 O15379 3/20 0.36
HDAC4 P56524 3/20 0.36
HDAC1 Q13547 3/20 0.36
HDAC7 Q8WUI4 3/20 0.36
HDAC2 Q92769 3/20 0.36
HDAC10 Q969S8 3/20 0.36
HDAC11 Q96DB2 3/20 0.36
HDAC8 Q9BY41 3/20 0.36
HDAC6 Q9UBN7 3/20 0.36
HDAC9 Q9UKV0 3/20 0.36
HDAC5 Q9UQL6 3/20 0.36
TDP2 O95551 1/20 0.36
LMNA P02545 1/20 0.36
CRHBP P24387 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3594528 0.92 RAF1 (0.46) RAF1KCNH2ALDH1A1KDM4EATM
SCHEMBL30953611 0.92 RAF1 (0.46) RAF1KCNH2ALDH1A1KDM4EATM
SCHEMBL3587235 0.89 ALDH1A1 (0.41) RAF1KCNH2ALDH1A1KDM4EATM
SCHEMBL30953734 0.89 ALDH1A1 (0.41) RAF1KCNH2ALDH1A1KDM4EATM
SCHEMBL3593417 0.83 KDM4E (0.50) RAF1KCNH2ALDH1A1KDM4EATM
SCHEMBL30953576 0.83 KDM4E (0.54) ALDH1A1KDM4EATMHTTHDAC3
SCHEMBL30953777 0.83 KDM4E (0.50) RAF1KCNH2ALDH1A1KDM4EATM
SCHEMBL30953605 0.82 KDM4E (0.55) ALDH1A1KDM4EATMHTTHDAC3
SCHEMBL30953642 0.82 KDM4E (0.55) ALDH1A1KDM4EATMHTTHDAC3
SCHEMBL11105631 0.82 KDM4E (0.55) ALDH1A1KDM4EATMHTTHDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024140431-A1 COMPOUNDS COMPRISING HETEROARYL RINGS AND COMPOSITIONS AND METHODS THEREOF IONGEN THERAPEUTICS CO., LTD. (CN) 2024-07-04 WO disclosed