Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glycinebetaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.39 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | CPT2 | P23786 | 1/20 | 0.37 |
| ▸ | CPT1A | P50416 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CRAT | P43155 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | BBOX1 | O75936 | 6/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycinebetaine SCHEMBL604825 | 0.97 | TSHR (0.52) | TSHRALDH1A1LMNAAPEX1SLC22A16 | |
| Glycinebetaine SCHEMBL132824 | 0.92 | — | — | |
| Glycinebetaine SCHEMBL7753166 | 0.90 | TSHR (0.46) | TSHRALDH1A1LMNAAPEX1SLC22A16 | |
| Glycinebetaine SCHEMBL9281697 | 0.89 | TSHR (0.55) | TSHRALDH1A1LMNAAPEX1SLC22A16 | |
| Glycinebetaine SCHEMBL2803780 | 0.89 | TSHR (0.53) | TSHRALDH1A1LMNAAPEX1SLC22A16 | |
| Glycinebetaine SCHEMBL7739 | 0.89 | — | — | |
| Betaine SCHEMBL31467313 | 0.89 | — | — | |
| Glycinebetaine SCHEMBL8678519 | 0.89 | TSHR (0.53) | TSHRALDH1A1LMNAAPEX1SLC22A16 | |
| Glycinebetaine SCHEMBL4900209 | 0.89 | — | — | |
| Glycinebetaine SCHEMBL11906100 | 0.87 | TSHR (0.48) | TSHRALDH1A1LMNAAPEX1SLC22A16 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100233444-A1 | Composition,article, its manufacture and use | IMAGICHEM LIMITED (GB) | 2010-09-16 | — | — | US | disclosed |
| EP-2035231-A2 | COMPOSITION, ARTICLE, ITS MANUFACTURE AND USE | Imagichem Limited (GB) | 2009-03-18 | — | — | EP | disclosed |
| WO-2008001127-A2 | COMPOSITION, ARTICLE, ITS MANUFACTURE AND USE | IMAGICHEM LIMITED (GB) | 2008-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100233444-A1 | Composition,article, its manufacture and use | DSTN, ING2, IGF1R | TSHR 2853/4885ALDH1A1 4438/4885LMNA 2148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.