Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.37 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | EGFR | P00533 | 3/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | PRKACG | P22612 | 1/20 | 0.34 |
| ▸ | PRKACB | P22694 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30955650 | 0.89 | ERN1 (0.38) | ERN1TNK2MAP4K2FGFR4MAPK8 | |
| SCHEMBL30955499 | 0.89 | TNK2 (0.47) | TNK2MAP4K2FGFR4 | |
| SCHEMBL30955648 | 0.86 | MAPK8 (0.37) | ERN1TNK2MAP4K2FGFR4MAPK8 | |
| SCHEMBL30955556 | 0.86 | ERN1 (0.43) | ERN1TNK2MAP4K2FGFR4MAPK8 | |
| SCHEMBL30955501 | 0.84 | ERN1 (0.39) | ERN1TNK2MAP4K2FGFR4MAPK8 | |
| SCHEMBL30955561 | 0.84 | ERN1 (0.43) | ERN1TNK2MAP4K2FGFR4MAPK8 | |
| SCHEMBL30955548 | 0.84 | ERN1 (0.43) | ERN1TNK2MAP4K2FGFR4MAPK8 | |
| SCHEMBL30955654 | 0.84 | FGFR1 (0.34) | ERN1FGFR4MAPK1FGFR1FGFR2 | |
| SCHEMBL30955560 | 0.84 | ERN1 (0.43) | ERN1TNK2MAP4K2FGFR4MAPK8 | |
| SCHEMBL30955490 | 0.84 | ERN1 (0.43) | ERN1TNK2MAP4K2FGFR4MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024131893-A1 | IRE1α SMALL MOLECULE INHIBITORS | SHANGHAI YI ZHONG XING BIOTECHNOLOGY CO., LTD. (CN) | 2024-06-27 | — | — | WO | disclosed |