Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.36 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 7/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.32 |
| ▸ | CDK4 | P11802 | 3/20 | 0.32 |
| ▸ | CCND1 | P24385 | 3/20 | 0.32 |
| ▸ | CDK2 | P24941 | 3/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CCND3 | P30281 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30955652 | 0.89 | ERN1 (0.39) | ERN1TNK2MAP4K2FGFR4MAPK8 | |
| SCHEMBL30955648 | 0.85 | MAPK8 (0.37) | ERN1TNK2MAP4K2FGFR4MAPK8 | |
| SCHEMBL30955617 | 0.82 | ERN1 (0.41) | ERN1TNK2MAP4K2FGFR4MAPK1 | |
| SCHEMBL30955556 | 0.82 | ERN1 (0.43) | ERN1TNK2MAP4K2FGFR4MAPK8 | |
| SCHEMBL30955563 | 0.82 | ERN1 (0.54) | ERN1TNK2MAP4K2FGFR4MAPK8 | |
| SCHEMBL30955598 | 0.82 | ERN1 (0.47) | ERN1TNK2MAP4K2FGFR4CDK2 | |
| SCHEMBL30955548 | 0.81 | ERN1 (0.43) | ERN1TNK2MAP4K2FGFR4MAPK8 | |
| SCHEMBL30955561 | 0.81 | ERN1 (0.43) | ERN1TNK2MAP4K2FGFR4MAPK8 | |
| SCHEMBL30955501 | 0.81 | ERN1 (0.39) | ERN1TNK2MAP4K2FGFR4MAPK8 | |
| SCHEMBL30955499 | 0.78 | TNK2 (0.47) | TNK2MAP4K2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024131893-A1 | IRE1α SMALL MOLECULE INHIBITORS | SHANGHAI YI ZHONG XING BIOTECHNOLOGY CO., LTD. (CN) | 2024-06-27 | — | — | WO | disclosed |