Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.54 |
| ▸ | JAK1 | P23458 | 7/20 | 0.54 |
| ▸ | JAK3 | P52333 | 7/20 | 0.54 |
| ▸ | FLT4 | P35916 | 2/20 | 0.53 |
| ▸ | TYK2 | P29597 | 4/20 | 0.52 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CDK7 | P50613 | 2/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30956582 | 0.87 | JAK2 (0.60) | JAK2JAK1JAK3FLT4TYK2 | |
| SCHEMBL30956477 | 0.84 | JAK3 (0.57) | JAK2JAK1JAK3TYK2AURKB | |
| SCHEMBL30956564 | 0.83 | JAK2 (0.56) | JAK2JAK1JAK3TYK2CDK2 | |
| SCHEMBL30956578 | 0.82 | JAK2 (0.58) | JAK2JAK1JAK3FLT4TYK2 | |
| SCHEMBL30956553 | 0.82 | CDK1 (0.56) | JAK2JAK1JAK3FLT4TYK2 | |
| SCHEMBL24853418 | 0.82 | AURKA (0.50) | JAK2JAK1JAK3FLT4TYK2 | |
| SCHEMBL31557670 | 0.82 | AURKA (0.50) | JAK2JAK1JAK3FLT4TYK2 | |
| SCHEMBL30956456 | 0.81 | MAP3K7 (0.58) | JAK2JAK1JAK3FLT4TYK2 | |
| SCHEMBL30956429 | 0.80 | JAK2 (0.47) | JAK2JAK1JAK3FLT4TYK2 | |
| SCHEMBL30956577 | 0.79 | JAK2 (0.53) | JAK2JAK1JAK3FLT4TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119118999-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-12-13 | — | — | CN | disclosed |
| CN-118955477-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-118903141-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-118903142-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-113227074-B | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-118388457-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-26 | — | — | CN | disclosed |
| CN-118290403-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-05 | — | — | CN | disclosed |