Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.49 |
| ▸ | JAK2 | O60674 | 11/20 | 0.49 |
| ▸ | JAK1 | P23458 | 10/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 4/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30956528 | 0.90 | JAK3 (0.48) | JAK3JAK2JAK1LRRK2CLK2 | |
| SCHEMBL30956497 | 0.85 | JAK3 (0.54) | JAK3JAK2JAK1LRRK2CLK2 | |
| SCHEMBL30956536 | 0.83 | JAK3 (0.56) | JAK3JAK2JAK1LRRK2CLK2 | |
| SCHEMBL30956568 | 0.83 | JAK3 (0.50) | JAK3JAK2JAK1LRRK2CLK2 | |
| SCHEMBL30956565 | 0.83 | JAK3 (0.51) | JAK3JAK2JAK1LRRK2CLK2 | |
| SCHEMBL22097812 | 0.81 | IKBKE (0.53) | JAK3JAK2JAK1LRRK2TYK2 | |
| SCHEMBL31557679 | 0.81 | IKBKE (0.53) | JAK3JAK2JAK1LRRK2TYK2 | |
| SCHEMBL30956377 | 0.79 | JAK3 (0.51) | JAK3JAK2JAK1TYK2IKBKE | |
| SCHEMBL30956373 | 0.76 | JAK3 (0.53) | JAK3JAK2JAK1LRRK2TYK2 | |
| SCHEMBL30956553 | 0.76 | CDK1 (0.56) | JAK3JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119118999-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-12-13 | — | — | CN | disclosed |
| CN-118955477-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-118903141-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-118903142-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-113227074-B | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-118388457-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-26 | — | — | CN | disclosed |
| CN-118290403-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-05 | — | — | CN | disclosed |