⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9729752 | 0.97 | CHRM2 (0.40) | — | |
| SCHEMBL11775357 | 0.97 | CHRM2 (0.40) | — | |
| SCHEMBL28190285 | 0.97 | CHRM2 (0.40) | — | |
| SCHEMBL735998 | 0.92 | — | — | |
| SCHEMBL27456365 | 0.87 | DNM1 (0.39) | — | |
| SCHEMBL401549 | 0.85 | CHRM2 (0.45) | — | |
| SCHEMBL9371017 | 0.82 | CHRM2 (0.52) | — | |
| SCHEMBL15958687 | 0.82 | CHRM2 (0.50) | — | |
| SCHEMBL13856002 | 0.82 | CHRM2 (0.50) | — | |
| SCHEMBL9579289 | 0.81 | DNM1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107468685-B | Pharmaceutical composition and compound for treating hypertension and heart failure | 科贝源(北京)生物医药科技有限公司 | 2021-06-01 | — | — | CN | disclosed |
| US-8217070-B2 | 2-substituted-1H-benzimidazole-4-carboxamides are PARP inhibitors | ABBOTT LABORATORIES (US) | 2012-07-10 | — | — | US | disclosed |
| US-20100234425-A1 | 2-SUBSTITUTED-1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE PARP INHIBITORS | ABBOTT LABORATORIES (US) | 2010-09-16 | — | — | US | disclosed |
| US-7728026-B2 | 2-substituted-1 h-benzimidazile-4-carboxamides are PARP inhibitors | ABBOTT LABORATORIES, INC. (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006110683-A1 | 2-SUBSTITUTED-1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE PARP INHIBITORS | ABBOTT LABORATORIES (US) | 2006-10-19 | — | — | WO | disclosed |
| US-20060229351-A1 | 2-Substituted-1 H-benzimidazile-4-carboxamides are PARP inhibitors | ABBVIE INC. | 2006-10-12 | — | — | US | disclosed |
| US-4760064-A | Cardiotonic agent | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-07-26 | — | — | US | disclosed |
| EP-0187322-A1 | Carbostyril compounds, compositions containing same and processes for preparing same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-07-16 | — | — | EP | disclosed |