Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29344216 | 0.78 | FFAR4 (0.30) | ERN1 | |
| SCHEMBL21196123 | 0.77 | ERN1 (0.34) | ERN1 | |
| SCHEMBL29344291 | 0.76 | EPAS1 (0.30) | — | |
| SCHEMBL30849780 | 0.74 | ERN1 (0.33) | ERN1 | |
| SCHEMBL31459749 | 0.74 | CYP1A2 (0.36) | ERN1 | |
| SCHEMBL21216165 | 0.72 | ERN1 (0.39) | ERN1 | |
| SCHEMBL21195865 | 0.71 | POLB (0.33) | ERN1 | |
| SCHEMBL29344302 | 0.71 | ERN1 (0.31) | ERN1 | |
| SCHEMBL16761914 | 0.71 | SRC (0.50) | MEN1KMT2A | |
| SCHEMBL25286626 | 0.70 | ERN1 (0.44) | ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709371-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | Merck Sharp & Dohme LLC (US) | 2026-03-18 | — | — | EP | disclosed |
| EP-4615847-A1 | SMALL MOLECULE INHIBITORS OF KRAS PROTEINS | Merck Sharp & Dohme LLC (US) | 2025-09-17 | — | — | EP | disclosed |
| WO-2024233776-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | MERCK SHARP & DOHME LLC (US) | 2024-11-14 | — | — | WO | disclosed |
| WO-2024103010-A1 | SMALL MOLECULE INHIBITORS OF KRAS PROTEINS | MERCK SHARP & DOHME LLC (US) | 2024-05-16 | — | — | WO | disclosed |