Levocarnitine

Levocarnitine

SCHEMBL309626

C[N+](C)(C)C[C@H](O)CC(=O)[O-].[Mg]

nearest known ligand 0.95

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC22A16 Q86VW1 1/20 0.95
CPT2 P23786 2/20 0.59
CPT1A P50416 2/20 0.59
MAPT P10636 2/20 0.58
MEN1 O00255 3/20 0.52
KMT2A Q03164 3/20 0.52
CYP1A2 P05177 1/20 0.52
HRH1 P35367 1/20 0.52
CRAT P43155 1/20 0.52
CYP2C19 P33261 2/20 0.48
RECQL P46063 1/20 0.48
CA4 P22748 2/20 0.42
CA2 P00918 1/20 0.42
SLC25A20 O43772 3/20 0.41
TP53 P04637 2/20 0.41
CYP2D6 P10635 2/20 0.41
TSHR P16473 2/20 0.41
CPT1B Q92523 1/20 0.41
KDM4E B2RXH2 1/20 0.41
CYP3A4 P08684 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Carnitine SCHEMBL1456180 1.00 SLC22A16 (0.95) SLC22A16CPT2CPT1AMAPTMEN1
Levocarnitine SCHEMBL4593172 0.98 SLC22A16 (1.00) SLC22A16CPT2CPT1AMAPTMEN1
Levocarnitine SCHEMBL21970 0.98 SLC22A16 (1.00) SLC22A16CPT2CPT1AMAPTMEN1
D-Carnitine SCHEMBL94286 0.98 SLC22A16 (1.00) SLC22A16CPT2CPT1AMAPTMEN1
Carnitine SCHEMBL17629811 0.98 SLC22A16 (1.00) SLC22A16CPT2CPT1AMAPTMEN1
Carnitine SCHEMBL3902633 0.98 SLC22A16 (1.00) SLC22A16CPT2CPT1AMAPTMEN1
Carnitine SCHEMBL21971 0.98 SLC22A16 (1.00) SLC22A16CPT2CPT1AMAPTMEN1
Carnitine SCHEMBL1813524 0.98 SLC22A16 (1.00) SLC22A16CPT2CPT1AMAPTMEN1
Levocarnitine SCHEMBL23249739 0.95 SLC22A16 (0.95) SLC22A16CPT2CPT1AMAPTMEN1
Carnitine SCHEMBL1456305 0.95 SLC22A16 (0.95) SLC22A16CPT2CPT1AMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090239914-A1 Phosphorus binder for treatment of renal disease BIOLINK LIFE SCIENCES, INC. 2009-09-24 US claimed
US-8093292-B2 Conjugated fatty acid or alcohol, thiol-containing compound and bioavailable form of trivalent chromium; preventing metabolic dysregulation of adipocytes resulting from HIV-1 infection or chronic inflammation BIONEXUS, LTD. (US) 2012-01-10 US disclosed
US-8034833-B2 Phosphorus binder for treatment of renal disease BIOLINK LIFE SCIENCES, INC. (US) 2011-10-11 US disclosed
EP-2170809-A2 METHODS FOR THE PREPARATION AND FORMULATION OF L-CARNITINE VALPROATE SALTS Biolink Life Sciences, Inc. (US) 2010-04-07 EP disclosed
US-20090239914-A1 Phosphorus binder for treatment of renal disease BIOLINK LIFE SCIENCES, INC. 2009-09-24 US disclosed
CN-101400270-A Composition for food and drink with improved hygroscopicity SUNTORY LTD (JP) 2009-04-01 CN disclosed
US-7456216-B2 Methods for the preparation and formulation of l-carnitine valproate salts BIOLINK LIFE SCIENCES, INC. (US) 2008-11-25 US disclosed
WO-2008116215-A2 PHOSPHORUS BINDER FOR TREATMENT OF RENAL DISEASE BIOLINK LIFE SCIENCES, INC. (US) 2008-09-25 WO disclosed
US-20080234378-A1 METHODS FOR THE PREPARATION AND FORMULATION OF L-CARNITINE VALPROATE SALTS BIOLINK LIFE SCIENCES, INC. 2008-09-25 US disclosed
WO-2008115920-A2 METHODS FOR THE PREPARATION AND FORMULATION OF L-CARNITINE VALPROATE SALTS BIOLINK LIFE SCIENCES, INC. (US) 2008-09-25 WO disclosed
US-20080114065-A1 Methods for the treatment of HIV-1 related fat maldistribution, fasting hyperlipidemia and modification of adipocyte physiology BIONEXUS, LTD. 2008-05-15 US disclosed
US-7060295-B2 Formulations for the prevention and treatment of insulin resistance and type 2 diabetes mellitus CHRONORX LLC (US) 2006-06-13 US disclosed
US-6693094-B2 SUPPORTING MITOCHONDRIAL METABOLISM WITH A UNIT DOSAGE FORM OF CHOLINE, ASCORBATE, L-CARNITINE, MAGNESIUM, TAURINE, FOLIC ACID AND METFORMIN CHRONO RX LLC 2004-02-17 US disclosed
US-6689385-B2 THERAPY FOR INSULIN RESISTANCE IN DIABETIC THERAPY CHRONORX LLC 2004-02-10 US disclosed
WO-2002059075-A1 SALTS OF CARNITINES USEFUL AS DIETARY/NUTRITIONAL SUPPLEMENTS OR DRUGS, PROCESSES FOR PREPARING SAME AND COMPOSITIONS CONTAINING SUCH SALTS FASSI, ALDO (IT) 2002-08-01 WO disclosed
EP-0971879-B1 SOLID COMPOSITIONS SUITABLE FOR ORAL ADMINISTRATION COMPRISING L-CARNITINE AND ALKANOYL-L-CARNITINE MAGNESIUM TARTRATE SIGMA TAU IND BR FARMACEUTICHE (IT) 2001-11-14 EP disclosed
US-6130249-A Solid compositions suitable for oral administration comprising L-carnitine and alkanoyl-L-carnitine magnesium tartrate SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) 2000-10-10 US disclosed
EP-0971879-A1 SOLID COMPOSITIONS SUITABLE FOR ORAL ADMINISTRATION COMPRISING L-CARNITINE AND ALKANOYL-L-CARNITINE MAGNESIUM TARTRATE Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) 2000-01-19 EP disclosed
WO-1998045250-A1 SOLID COMPOSITIONS SUITABLE FOR ORAL ADMINISTRATION COMPRISING L-CARNITINE AND ALKANOYL-L-CARNITINE MAGNESIUM TARTRATE SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) 1998-10-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090239914-A1 Phosphorus binder for treatment of renal disease ALPI, PHPT1, FABP2 SLC22A16 246/4885CPT2 3417/4885CPT1A 1258/4885
US-20080234378-A1 METHODS FOR THE PREPARATION AND FORMULATION OF L-CARNITINE VALPROATE SALTS CPT1B, CPT1A, CRAT SLC22A16 381/4885CPT2 4/4885CPT1A 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.