Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.57 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 3/20 | 0.50 |
| ▸ | PNMT | P11086 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | AGXT | P21549 | 2/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.49 |
| ▸ | HTR3B | O95264 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7901300 | 0.85 | ENPP2 (0.46) | TAAR1AOC3CHRM2CHRM1CHRM3 | |
| SCHEMBL11507348 | 0.83 | TAAR1 (0.45) | TAAR1AOC3IDO1CYP3A4AGXT | |
| SCHEMBL12050856 | 0.80 | TAAR1 (0.74) | TAAR1AOC3IDO1PNMTCYP3A4 | |
| SCHEMBL22519891 | 0.79 | CYP3A4 (0.55) | TAAR1IDO1PNMTCYP3A4AGXT | |
| SCHEMBL791970 | 0.79 | CYP3A4 (0.64) | TAAR1IDO1PNMTCYP3A4AGXT | |
| SCHEMBL23149258 | 0.79 | IDO1 (0.43) | IDO1 | |
| SCHEMBL10204841 | 0.78 | TAAR1 (0.59) | TAAR1IDO1 | |
| SCHEMBL16858350 | 0.78 | ENPP2 (0.42) | TAAR1CHRM2CHRM1CHRM3 | |
| SCHEMBL13548270 | 0.78 | KDM4E (0.47) | TAAR1CHRM2CHRM1CHRM3 | |
| SCHEMBL3889869 | 0.77 | TAAR1 (0.53) | TAAR1AOC3IDO1PNMTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015078374-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2015-06-04 | — | — | WO | disclosed |
| US-8722942-B2 | Method for producing biphenyl derivative | TORAY FINE CHEMICALS CO., LTD. (JP) | 2014-05-13 | — | — | US | disclosed |
| EP-2075241-B1 | METHOD FOR PRODUCING A BIPHENYL DERIVATIVE | TORAY FINECHEMICALS CO LTD (JP) | 2013-09-25 | — | — | EP | disclosed |
| US-8440706-B2 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-05-14 | — | — | US | disclosed |
| US-8372873-B2 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-02-12 | — | — | US | disclosed |
| US-20100230634-A1 | METHOD FOR PRODUCING BIPHENYL DERIVATIVE | Hayashi, Tamio (JP) | 2010-09-16 | — | — | US | disclosed |
| EP-2075241-A1 | METHOD FOR PRODUCING BIPHENYL DERIVATIVE | Toray Fine Chemicals Co., Ltd. (JP) | 2009-07-01 | — | — | EP | disclosed |
| EP-0531715-B1 | Process for producing alcohols and ketones | SUMITOMO CHEMICAL CO (JP) | 1997-11-05 | — | — | EP | disclosed |
| US-5426237-A | Oxidation of straight, branched or cyclic alkanes and benzene derivatives in presence of transition metal catalyst and aldehyde | SUMITOMO CHEMICAL CO., LTD. (JP) | 1995-06-20 | — | — | US | disclosed |
| EP-0531715-A1 | Process for producing alcohols and ketones | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1993-03-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100230634-A1 | METHOD FOR PRODUCING BIPHENYL DERIVATIVE | CYP2E1, DDT, B2M | TAAR1 4209/4885AOC3 1215/4885IDO1 2296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.