Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.38 |
| ▸ | USP2 | O75604 | 4/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30964359 | 0.91 | EGFR (0.45) | EGFRCYP3A4CYP1A2CLK4ALDH1A1 | |
| SCHEMBL30964408 | 0.88 | EGFR (0.43) | EGFRCYP3A4CYP1A2CLK4ALDH1A1 | |
| SCHEMBL30964485 | 0.86 | IRAK4 (0.44) | EGFRCYP3A4CYP1A2CLK4ALDH1A1 | |
| SCHEMBL4352943 | 0.85 | EGFR (0.48) | EGFRCYP3A4CYP1A2CLK4ALDH1A1 | |
| SCHEMBL30964385 | 0.82 | EGFR (0.39) | EGFRCYP3A4CYP1A2CLK4ALDH1A1 | |
| SCHEMBL30964500 | 0.82 | EGFR (0.51) | EGFRCYP3A4CYP1A2CLK4ALDH1A1 | |
| SCHEMBL30964394 | 0.82 | EGFR (0.40) | EGFRCYP3A4CYP1A2CLK4ALDH1A1 | |
| SCHEMBL30964454 | 0.82 | AKT1 (0.42) | EGFRCYP3A4CYP1A2CLK4LMNA | |
| SCHEMBL30964351 | 0.82 | EGFR (0.41) | EGFRCYP3A4CYP1A2CLK4ALDH1A1 | |
| SCHEMBL30964368 | 0.81 | EGFR (0.39) | EGFRCYP3A4CYP1A2CLK4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4605089-A1 | COMPOUNDS USEFUL IN MODULATING EGFR AND PI3K | Mekanistic Therapeutics LLC (US) | 2025-08-27 | — | — | EP | disclosed |
| WO-2024086296-A1 | COMPOUNDS USEFUL IN MODULATING EGFR AND PI3K | MEKANISTIC THERAPEUTICS LLC (US) | 2024-04-25 | — | — | WO | disclosed |