SCHEMBL4352943

SCHEMBL4352943

Clc1ccc2c(c1)N(c1ncnc3ccc(-c4ccccc4)cc13)CC2

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 4/20 0.48
CSF1R P07333 1/20 0.47
AKT1 P31749 1/20 0.46
MAP4K4 O95819 4/20 0.46
CYP1A2 P05177 10/20 0.45
CYP3A4 P08684 10/20 0.45
CLK4 Q9HAZ1 9/20 0.45
LMNA P02545 6/20 0.45
ALDH1A1 P00352 6/20 0.45
MAPK1 P28482 5/20 0.45
HIF1A Q16665 5/20 0.45
USP2 O75604 5/20 0.45
CYP2C19 P33261 4/20 0.45
CYP2D6 P10635 3/20 0.45
TSHR P16473 2/20 0.45
HSD17B10 Q99714 2/20 0.45
MEN1 O00255 4/20 0.43
KMT2A Q03164 4/20 0.43
ALOX15 P16050 1/20 0.43
HTT P42858 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30964408 0.87 EGFR (0.43) EGFRCSF1RAKT1MAP4K4CYP1A2
SCHEMBL30964359 0.86 EGFR (0.45) EGFRCSF1RAKT1MAP4K4CYP1A2
SCHEMBL30964508 0.85 EGFR (0.44) EGFRCSF1RAKT1MAP4K4CYP1A2
SCHEMBL8090078 0.84 EGFR (0.48) EGFRCSF1RAKT1CYP1A2CYP2D6
SCHEMBL30964485 0.83 IRAK4 (0.44) EGFRCSF1RAKT1MAP4K4CYP1A2
SCHEMBL8646161 0.83 EGFR (0.48) EGFRCSF1RAKT1MAP4K4CYP1A2
Hydrochloric Acid SCHEMBL8646103 0.83 EGFR (0.47) EGFRCSF1RAKT1CYP1A2CYP2D6
SCHEMBL30964366 0.82 EGFR (0.40) EGFRCSF1RAKT1MAP4K4CYP1A2
SCHEMBL30964500 0.81 EGFR (0.51) EGFRCSF1RCYP1A2CYP3A4CLK4
SCHEMBL30964354 0.81 CYP1A2 (0.47) EGFRCSF1RMAP4K4CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009070328-A1 MODULATORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PATHWAY FOR USE IN THE TREATMENT OR PREVENTION OF SUBSTANCE ABUSE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2009-06-04 WO disclosed
US-6225318-B1 4-aminoquinazolone derivatives PFIZER INC 2001-05-01 US disclosed
EP-0837063-A1 4-Aminoquinazoline derivatives PFIZER INC. (US) 1998-04-22 EP disclosed