Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763827 | 0.82 | PARP1 (0.54) | PARP1AURKARPS6KB1KMT2AMEN1 | |
| SCHEMBL30937791 | 0.72 | PARP1 (0.50) | PARP1AURKARPS6KB1KMT2AMEN1 | |
| SCHEMBL3330917 | 0.72 | PARP1 (0.50) | PARP1AURKARPS6KB1KMT2AMEN1 | |
| SCHEMBL8081042 | 0.69 | KMT2A (0.42) | KMT2AMEN1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL368712 | 0.69 | BCL2L1 (0.41) | PARP1KMT2AMEN1RAB9ASMN1; SMN2 | |
| SCHEMBL30839564 | 0.69 | PARP1 (0.46) | PARP1AURKARPS6KB1SMN1; SMN2ALDH1A1 | |
| SCHEMBL30969102 | 0.68 | MAPT (0.47) | KMT2AMEN1RAB9AALDH1A1HPGD | |
| SCHEMBL4566904 | 0.67 | HSD17B10 (0.41) | KMT2AMEN1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6436615 | 0.67 | HSD17B10 (0.41) | KMT2AMEN1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3675628 | 0.66 | POLB (0.46) | PARP1AURKARPS6KB1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024140968-A1 | TRICYCLIC COMPOUND, AND PREPARATION METHOD AND USE THEREFOR | 广州市联瑞制药有限公司 | 2024-07-04 | — | — | WO | disclosed |