Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 5/20 | 0.67 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.67 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.67 |
| ▸ | CNR2 | P34972 | 1/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.67 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 2/20 | 0.37 |
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3090845 | 0.89 | CACNA1I (0.50) | CACNA1ICACNA1HCACNA1GCNR2KCNH2 | |
| SCHEMBL3096368 | 0.87 | CACNA1I (0.67) | CACNA1ICACNA1HCACNA1GCNR2KCNH2 | |
| SCHEMBL23328121 | 0.87 | CACNA1I (0.52) | CACNA1ICACNA1HCACNA1GCNR2KCNH2 | |
| SCHEMBL3093274 | 0.85 | CACNA1I (0.47) | CACNA1ICACNA1HCACNA1GCNR2KCNH2 | |
| SCHEMBL3096617 | 0.84 | CACNA1I (0.48) | CACNA1ICACNA1HCACNA1GCNR2KCNH2 | |
| SCHEMBL3095548 | 0.84 | CACNA1I (0.65) | CACNA1ICACNA1HCACNA1GCNR2KCNH2 | |
| SCHEMBL3090917 | 0.83 | CACNA1I (0.64) | CACNA1ICACNA1HCACNA1GCNR2KCNH2 | |
| SCHEMBL3102313 | 0.83 | CACNA1I (0.64) | CACNA1ICACNA1HCACNA1GCNR2KCNH2 | |
| SCHEMBL3105419 | 0.83 | CACNA1I (0.64) | CACNA1ICACNA1HCACNA1GCNR2KCNH2 | |
| SCHEMBL3099386 | 0.83 | CACNA1I (0.66) | CACNA1ICACNA1HCACNA1GCNR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249176-A1 | HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | BARROW JAMES C | 2010-09-30 | — | — | US | claimed |
| EP-2212293-A1 | HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | Merck Sharp & Dohme Corp. (US) | 2010-08-04 | — | — | EP | claimed |
| WO-2009054983-A1 | HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2009-04-30 | — | — | WO | claimed |
| US-20210128537-A1 | T-TYPE CALCIUM CHANNEL MODULATORS AND METHODS OF USE THEREOF | PRAXIS PREC MEDICINES INC (US) | 2021-05-06 | — | — | US | disclosed |
| US-20210038589-A1 | USES, COMPOSITIONS AND METHODS | FISAHN ANDRE (SE) | 2021-02-11 | — | — | US | disclosed |
| US-20100249176-A1 | HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | BARROW JAMES C | 2010-09-30 | — | — | US | disclosed |
| US-20100249176-A1 | HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | BARROW JAMES C | 2010-09-30 | — | — | US | disclosed |
| US-20100249176-A1 | HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | BARROW JAMES C | 2010-09-30 | — | — | US | disclosed |
| WO-2009054983-A1 | HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2009-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210038589-A1 | USES, COMPOSITIONS AND METHODS | APP, CACNA1G, CACNA1B | CACNA1I 5/4885CACNA1H 11/4885CACNA1G 2/4885 |
| US-20100249176-A1 | HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | CACNA1G, CACNA1H, CACNA1I | CACNA1I 3/4885CACNA1H 2/4885CACNA1G 1/4885 |
| US-20210128537-A1 | T-TYPE CALCIUM CHANNEL MODULATORS AND METHODS OF USE THEREOF | CACNA1G, CACNA1H, CACNA1I | CACNA1I 3/4885CACNA1H 2/4885CACNA1G 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.