Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.43 |
| ▸ | CHKA known ✓ | P35790 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27392955 | 0.98 | MAPT (0.51) | MEN1ALDH1A1MAPTKMT2AGAA | |
| SCHEMBL27392934 | 0.82 | GSK3B (0.66) | MAPTKMT2AGAAATMHTT | |
| Bromide SCHEMBL140800 | 0.80 | LMNA (0.55) | ALDH1A1CHKASMN1; SMN2HTT | |
| SCHEMBL12267728 | 0.79 | CA1 (0.59) | KMT2ASMN1; SMN2 | |
| SCHEMBL736568 | 0.78 | LMNA (0.56) | ALDH1A1MAPTCHKAGAASMN1; SMN2 | |
| SCHEMBL18775302 | 0.78 | KMT2A (0.53) | ALDH1A1MAPTKMT2ABCHEACHE | |
| SCHEMBL19661290 | 0.78 | KMT2A (0.47) | MAPTKMT2ABCHEACHECHKA | |
| SCHEMBL7837346 | 0.78 | CHKA (0.49) | ALDH1A1BCHEACHECHKA | |
| Bromide SCHEMBL10914760 | 0.77 | CHKA (0.55) | BCHEACHECHKASMN1; SMN2HTT | |
| Bromide SCHEMBL10917081 | 0.77 | CHKA (0.47) | BCHEACHECHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4640685-A1 | PRODUCTION INTERMEDIATE | Carna Biosciences, Inc. (JP) | 2025-10-29 | — | — | EP | disclosed |
| WO-2024134859-A1 | PRODUCTION INTERMEDIATE | カルナバイオサイエンス株式会社 | 2024-06-27 | — | — | WO | disclosed |