Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | OGA | O60502 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2558135 | 0.86 | ALDH1A1 (0.44) | ALDH1A1HSD17B10TDP1MAPTKDM4E | |
| SCHEMBL5508716 | 0.83 | ALDH1A1 (0.42) | ALDH1A1HSD17B10TDP1MAPTMEN1 | |
| SCHEMBL9617823 | 0.81 | ALDH1A1 (0.40) | ALDH1A1HSD17B10TDP1MAPTKDM4E | |
| SCHEMBL9679204 | 0.79 | ALDH1A1 (0.41) | ALDH1A1HSD17B10TDP1MAPTKDM4E | |
| SCHEMBL30340334 | 0.77 | ALDH1A1 (0.42) | ALDH1A1HSD17B10TDP1MAPTKDM4E | |
| SCHEMBL6156507 | 0.77 | ALDH1A1 (0.42) | ALDH1A1HSD17B10TDP1MAPTKDM4E | |
| SCHEMBL9054394 | 0.77 | ALDH1A1 (0.42) | ALDH1A1HSD17B10TDP1KDM4ETSHR | |
| SCHEMBL27762198 | 0.76 | MAPT (0.63) | ALDH1A1HSD17B10TDP1MAPTKDM4E | |
| SCHEMBL31085276 | 0.75 | ALDH1A1 (0.56) | ALDH1A1HSD17B10TDP1MAPTKDM4E | |
| SCHEMBL12180466 | 0.74 | KDM4E (0.38) | ALDH1A1OGAMAPTKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093406-B2 | Cyclic sulfones with aminobenzyl substitution useful as BACE inhibitors | NOVARTIS AG (CH) | 2012-01-10 | — | — | US | disclosed |
| EP-2303857-A1 | CYCLIC SULFONES WITH AMINOBENZYL SUBSTITUTION USEFUL AS BACE INHIBITORS | Novartis AG (CH) | 2011-04-06 | — | — | EP | disclosed |
| US-20100056490-A1 | Cyclic sulfones with aminobenzyl substitution useful as BACE inhibitors | NOVARTIS AG (CH) | 2010-03-04 | — | — | US | disclosed |
| WO-2010003976-A1 | CYCLIC SULFONES WITH AMINOBENZYL SUBSTITUTION USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2010-01-14 | — | — | WO | disclosed |
| EP-0473041-A1 | 2,3-Dihydrobenzofurylmethylesters, their preparation and compositions containing these for combatting parasites | BASF Aktiengesellschaft (DE) | 1992-03-04 | — | — | EP | disclosed |
| EP-0023637-B1 | SUBSTITUTED 2,3-DIHYDROBENZOFURYLMETHYL-CYCLOPROPANECARBOXYLIC ACID ESTERS, PROCESS FOR THEIR PREPARATION, PROCESS FOR COMBATTING PARASITES, AND AGENTS THEREFOR | BASF Aktiengesellschaft (DE) | 1984-04-04 | — | — | EP | disclosed |
| US-4298615-A | INSECTICIDES, MITICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1981-11-03 | — | — | US | disclosed |
| EP-0023637-A1 | Substituted 2,3-dihydrobenzofurylmethyl-cyclopropanecarboxylic acid esters, process for their preparation, process for combatting parasites, and agents therefor | BASF Aktiengesellschaft (DE) | 1981-02-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056490-A1 | Cyclic sulfones with aminobenzyl substitution useful as BACE inhibitors | BACE2, BACE1, APP | ALDH1A1 2566/4885HSD17B10 2690/4885TDP1 1554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.