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Sugi Predict / Compounds / SCHEMBL30981012

SCHEMBL30981012

SCHEMBL30981012

CC(C)(C)OC(=O)NN1CCC(CCN2CCN(c3ccc(N4CCC(=O)NC4=O)cc3)CC2)CC1

nearest known ligand 0.45

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ DDB1 Q16531 6/20 0.45
▸ CRBN Q96SW2 6/20 0.45
▸ DRD2 P14416 10/20 0.43
▸ DRD3 P35462 8/20 0.43
▸ DRD4 P21917 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30981140 0.85 DDB1 (0.52) DDB1CRBNDRD2DRD3
SCHEMBL30981430 0.85 CRBN (0.45) DDB1CRBNDRD2DRD3
SCHEMBL30135897 0.82 DDB1 (0.43) DDB1CRBNDRD2
SCHEMBL30981408 0.81 CRBN (0.42) DDB1CRBNDRD2DRD3
SCHEMBL30965565 0.81 DDB1 (0.53) DDB1CRBNDRD2DRD3
SCHEMBL29680752 0.81 DRD2 (0.55) DDB1CRBNDRD2DRD4
SCHEMBL25941644 0.80 DDB1 (0.45) DDB1CRBN
SCHEMBL25123194 0.80 DDB1 (0.52) DDB1CRBNDRD2
SCHEMBL30981119 0.80 CRBN (0.40) DDB1CRBNDRD2DRD3
SCHEMBL23173823 0.79 DRD2 (0.57) DDB1CRBNDRD2DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4652161-A1 2,4-DIANILINOPYRIMIDINE-BASED AURORA-A KINASE SELECTIVE DEGRADATION INDUCING COMPOUNDS Uppthera, Inc. (KR) 2025-11-26 — — EP disclosed
WO-2024155112-A1 2,4-DIANILINOPYRIMIDINE-BASED AURORA-A KINASE SELECTIVE DEGRADATION INDUCING COMPOUNDS UPPTHERA, INC. (KR) 2024-07-25 — — WO disclosed