Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MGLL | Q99685 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21383560 | 0.87 | MEN1 (0.46) | TDP1L3MBTL1MGLLMEN1ALDH1A1 | |
| SCHEMBL27634597 | 0.83 | L3MBTL1 (0.74) | TDP1L3MBTL1MEN1KMT2AKCNA3 | |
| SCHEMBL7226815 | 0.82 | TDP1 (0.44) | TDP1L3MBTL1MEN1ALDH1A1RECQL | |
| SCHEMBL4165517 | 0.81 | L3MBTL1 (0.55) | TDP1L3MBTL1MGLLMEN1KMT2A | |
| SCHEMBL4337813 | 0.81 | MEN1 (0.68) | L3MBTL1MEN1ALDH1A1RECQLKMT2A | |
| SCHEMBL2640223 | 0.81 | TSHR (0.70) | TDP1L3MBTL1KCNA3TSHR | |
| SCHEMBL6373824 | 0.81 | SRD5A2 (0.58) | L3MBTL1MEN1ALDH1A1RECQLKMT2A | |
| SCHEMBL28156792 | 0.80 | FFAR1 (0.60) | TDP1L3MBTL1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL16594362 | 0.80 | TSHR (0.56) | TDP1L3MBTL1CYP1A2CYP2C19TSHR | |
| SCHEMBL15079872 | 0.80 | NPC1 (0.69) | TDP1L3MBTL1CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367702-B2 | Quinolone derivative | ASTELLAS PHARMA INC. (JP) | 2013-02-05 | — | — | US | disclosed |
| US-8367702-B2 | Quinolone derivative | ASTELLAS PHARMA INC. (JP) | 2013-02-05 | — | — | US | disclosed |
| US-20100256113-A1 | QUINOLONE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2010-10-07 | — | — | US | disclosed |
| US-20100256113-A1 | QUINOLONE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2010-10-07 | — | — | US | disclosed |
| CN-101801933-A | quinolone derivative | ASTELLAS PHARMA INC | 2010-08-11 | — | — | CN | disclosed |
| EP-2194044-A1 | QUINOLONE DERIVATIVE | Astellas Pharma Inc. (JP) | 2010-06-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256113-A1 | QUINOLONE DERIVATIVE | NQO1, NQO2, NADK | TDP1 3099/4885L3MBTL1 2056/4885MGLL 393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.