Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 4/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31269045 | 0.93 | PIK3CD (0.32) | PDE2APDE10APIK3CDKCNH2SCN5A | |
| SCHEMBL31269009 | 0.92 | PDE2A (0.36) | PDE2APDE10APIK3CDKCNH2SCN5A | |
| SCHEMBL31268869 | 0.91 | PIK3CD (0.32) | PIK3CDKCNH2SCN5ASCN9A | |
| SCHEMBL30983456 | 0.90 | PIK3CD (0.35) | PDE2APDE10APIK3CDKCNH2SCN5A | |
| SCHEMBL31269380 | 0.90 | PDE2A (0.38) | PDE2APDE10APIK3CDKCNH2SCN5A | |
| SCHEMBL31268950 | 0.90 | KCNH2 (0.32) | PIK3CDKCNH2SCN5ASCN9A | |
| SCHEMBL31268935 | 0.89 | PDE2A (0.34) | PDE2APDE10APIK3CDKCNH2SCN5A | |
| SCHEMBL30983461 | 0.88 | PDE2A (0.34) | PDE2APDE10APIK3CDKCNH2SCN5A | |
| SCHEMBL30983382 | 0.88 | PDE2A (0.34) | PDE2APDE10APIK3CDKCNH2SCN5A | |
| SCHEMBL31269061 | 0.88 | MET (0.33) | PDE2APDE10APIK3CDKCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4630410-A1 | POLQ INHIBITORS | Astrazeneca AB (SE) | 2025-10-15 | — | — | EP | claimed |
| WO-2024121753-A1 | POLQ INHIBITORS | ASTRAZENECA AB (SE) | 2024-06-13 | — | — | WO | claimed |
| EP-4689155-A1 | USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS | Astrazeneca AB (SE) | 2026-02-11 | — | — | EP | disclosed |
| EP-4630410-A1 | POLQ INHIBITORS | Astrazeneca AB (SE) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024201368-A1 | USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS | ASTRAZENECA AB (SE) | 2024-10-03 | — | — | WO | disclosed |
| WO-2024121753-A1 | POLQ INHIBITORS | ASTRAZENECA AB (SE) | 2024-06-13 | — | — | WO | disclosed |