Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.37 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 4/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30983826 | 0.91 | PIK3CD (0.39) | PIK3CDPDE10ADAPK1CNR1CNR2 | |
| SCHEMBL31269290 | 0.89 | PIK3CD (0.37) | PIK3CDPDE10AADORA2AADORA1CNR1 | |
| SCHEMBL30983433 | 0.89 | CNR1 (0.41) | PIK3CDPDE10ACNR1CNR2 | |
| SCHEMBL30983776 | 0.88 | PIK3CD (0.40) | PIK3CDPDE10ADAPK1ADORA2AADORA1 | |
| SCHEMBL30983784 | 0.88 | PIK3CD (0.40) | PIK3CDPDE10ADAPK1ADORA2AADORA1 | |
| SCHEMBL30983539 | 0.88 | PIK3CD (0.37) | PIK3CDADORA2AADORA1CNR1CNR2 | |
| SCHEMBL30983817 | 0.88 | CNR1 (0.41) | PIK3CDPDE10ACNR1CNR2KMT2A | |
| SCHEMBL30983496 | 0.87 | PIK3CD (0.37) | PIK3CD | |
| SCHEMBL30983791 | 0.87 | PIK3CD (0.36) | PIK3CDPDE10ADAPK1CNR1CNR2 | |
| SCHEMBL30983827 | 0.86 | PIK3CD (0.38) | PIK3CDPDE10ADAPK1ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4689155-A1 | USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS | Astrazeneca AB (SE) | 2026-02-11 | — | — | EP | disclosed |
| EP-4630410-A1 | POLQ INHIBITORS | Astrazeneca AB (SE) | 2025-10-15 | — | — | EP | disclosed |
| US-12414954-B2 | POLQ inhibitors | ASTRAZENECA AB (SE) | 2025-09-16 | — | — | US | disclosed |
| US-20250195530-A1 | POLQ INHIBITORS | ASTRAZENECA AB (SE) | 2025-06-19 | — | — | US | disclosed |
| US-20240366615-A1 | POLQ INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 2024-11-07 | — | — | US | disclosed |
| WO-2024201368-A1 | USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS | ASTRAZENECA AB (SE) | 2024-10-03 | — | — | WO | disclosed |
| WO-2024121753-A1 | POLQ INHIBITORS | ASTRAZENECA AB (SE) | 2024-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240366615-A1 | POLQ INHIBITORS | POLQ, POLG, POLB | PIK3CD 434/4885PDE10A 1995/4885CSNK2A1 191/4885 |
| US-12414954-B2 | POLQ inhibitors | POLQ, POLG, POLB | PIK3CD 434/4885PDE10A 1995/4885CSNK2A1 191/4885 |
| US-20250195530-A1 | POLQ INHIBITORS | POLQ, POLG, POLB | PIK3CD 434/4885PDE10A 1995/4885CSNK2A1 191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.