⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31321965 | 0.85 | — | — | |
| SCHEMBL30984078 | 0.78 | — | — | |
| SCHEMBL1398865 | 0.76 | QPCT (0.46) | — | |
| SCHEMBL30984077 | 0.71 | FLT3 (0.34) | — | |
| SCHEMBL4163924 | 0.70 | CNR2 (0.35) | — | |
| SCHEMBL10471467 | 0.68 | CCNK (0.39) | — | |
| SCHEMBL31732874 | 0.68 | KRAS (0.36) | — | |
| SCHEMBL30850504 | 0.67 | EGFR (0.36) | — | |
| SCHEMBL5440110 | 0.65 | CYP1A2 (0.48) | — | |
| SCHEMBL30983799 | 0.64 | PDPK1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4630410-A1 | POLQ INHIBITORS | Astrazeneca AB (SE) | 2025-10-15 | — | — | EP | disclosed |
| US-12414954-B2 | POLQ inhibitors | ASTRAZENECA AB (SE) | 2025-09-16 | — | — | US | disclosed |
| US-20250195530-A1 | POLQ INHIBITORS | ASTRAZENECA AB (SE) | 2025-06-19 | — | — | US | disclosed |
| US-20240366615-A1 | POLQ INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 2024-11-07 | — | — | US | disclosed |
| WO-2024121753-A1 | POLQ INHIBITORS | ASTRAZENECA AB (SE) | 2024-06-13 | — | — | WO | disclosed |