Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.49 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30983792 | 0.76 | HRH4 (0.43) | HRH4 | |
| SCHEMBL30983822 | 0.74 | DRD2 (0.42) | HRH4KDM4EALDH1A1DRD2MEN1 | |
| SCHEMBL30983415 | 0.74 | HRH4 (0.42) | HRH4KDM4EALDH1A1DRD2MEN1 | |
| SCHEMBL30983520 | 0.74 | HRH4 (0.42) | HRH4KDM4EALDH1A1DRD2MEN1 | |
| SCHEMBL30983423 | 0.73 | HRH4 (0.41) | HRH4KDM4EALDH1A1DRD2MEN1 | |
| SCHEMBL30983571 | 0.73 | DRD2 (0.41) | HRH4KDM4EALDH1A1DRD2MEN1 | |
| SCHEMBL30983511 | 0.73 | HRH4 (0.41) | HRH4KDM4EALDH1A1DRD2MEN1 | |
| SCHEMBL30983816 | 0.72 | HRH4 (0.40) | HRH4KDM4EALDH1A1DRD2MEN1 | |
| SCHEMBL30983428 | 0.72 | KMT2A (0.43) | HRH4KDM4EALDH1A1DRD2MEN1 | |
| SCHEMBL30984011 | 0.71 | KDM4E (0.42) | HRH4KDM4EALDH1A1DRD2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4689155-A1 | USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS | Astrazeneca AB (SE) | 2026-02-11 | — | — | EP | disclosed |
| EP-4630410-A1 | POLQ INHIBITORS | Astrazeneca AB (SE) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024201368-A1 | USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS | ASTRAZENECA AB (SE) | 2024-10-03 | — | — | WO | disclosed |
| WO-2024121753-A1 | POLQ INHIBITORS | ASTRAZENECA AB (SE) | 2024-06-13 | — | — | WO | disclosed |