Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WRN | Q14191 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 4/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30038855 | 0.89 | WRN (0.57) | WRNACHEPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL25037173 | 0.89 | WRN (0.57) | WRNACHEPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL30984258 | 0.87 | WRN (0.73) | WRNACHEPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL25037162 | 0.87 | WRN (0.58) | WRNACHEPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL25035041 | 0.86 | WRN (0.63) | WRNACHEPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL30039192 | 0.86 | WRN (0.63) | WRNACHEPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL27377823 | 0.85 | WRN (0.66) | WRNACHEPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL30037479 | 0.84 | WRN (0.55) | WRNACHEPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL30984226 | 0.83 | WRN (0.58) | WRNACHEPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL25035209 | 0.83 | WRN (0.51) | WRNPOLBL3MBTL1ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024153155-A1 | DOUBLE-HETEROCYCLIC WRN INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 成都微芯药业有限公司 | 2024-07-25 | — | — | WO | disclosed |