SCHEMBL30985196

SCHEMBL30985196

O=C1CCC(N2Cc3ncc(N4CCC5(CC4)CCN(C4CCN(c6ccc([N+](=O)[O-])cc6)CC4)C5)cc3C2=O)C(=O)N1

nearest known ligand 0.40

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 16/20 0.40
▸ DDB1 Q16531 1/20 0.40
▸ WIZ O95785 1/20 0.38
▸ IKZF2 Q9UKS7 2/20 0.37
▸ MEN1 O00255 1/20 0.35
▸ KMT2A Q03164 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30985042 0.90 MEN1 (0.42) CRBNDDB1WIZIKZF2MEN1
SCHEMBL30984826 0.89 CRBN (0.45) CRBNDDB1WIZIKZF2
SCHEMBL30984708 0.86 CRBN (0.47) CRBNDDB1WIZIKZF2
SCHEMBL30985024 0.83 CRBN (0.41) CRBNDDB1WIZIKZF2
SCHEMBL30985238 0.82 CRBN (0.61) CRBNDDB1IKZF2
SCHEMBL30985108 0.79 CRBN (0.46) CRBNDDB1WIZIKZF2
SCHEMBL30985114 0.79 CRBN (0.46) CRBNDDB1IKZF2MEN1KMT2A
SCHEMBL30984990 0.79 CRBN (0.59) CRBNDDB1MEN1KMT2A
SCHEMBL30985007 0.77 CRBN (0.62) CRBNDDB1MEN1KMT2A
SCHEMBL30984986 0.77 CRBN (0.62) CRBNDDB1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024146502-A1 WEE1 DEGRADING COMPOUNDS BEIJING NEOX BIOTECH LIMITED (CN) 2024-07-11 — — WO disclosed
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