Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lithium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | APAF1 | O14727 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2230708 | 0.99 | HTT (0.52) | HTTSMN1; SMN2MAPTMEN1APAF1 | |
| SCHEMBL2513610 | 0.94 | HTT (0.61) | HTTSMN1; SMN2MAPTMEN1APAF1 | |
| SCHEMBL7195915 | 0.94 | HTT (0.61) | HTTSMN1; SMN2MAPTMEN1APAF1 | |
| SCHEMBL14720371 | 0.94 | HTT (0.61) | HTTSMN1; SMN2MAPTMEN1APAF1 | |
| SCHEMBL4261223 | 0.89 | HTT (0.56) | HTTSMN1; SMN2MAPTMEN1APAF1 | |
| SCHEMBL4457301 | 0.88 | MAPT (0.52) | HTTSMN1; SMN2MAPTMEN1APAF1 | |
| SCHEMBL52073 | 0.85 | HTT (0.42) | HTTSMN1; SMN2MAPTMEN1APAF1 | |
| SCHEMBL16934931 | 0.85 | HTT (0.42) | HTTSMN1; SMN2MAPTMEN1APAF1 | |
| SCHEMBL2295678 | 0.85 | FDPS (0.43) | HTTSMN1; SMN2MEN1HSP90AA1KMT2A | |
| SCHEMBL2913208 | 0.84 | HTT (0.45) | HTTSMN1; SMN2MAPTMEN1APAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118393788-B | Ion conducting layer for electrochromic device, preparation method of ion conducting layer, electrochromic device and application of ion conducting layer | 比亚迪股份有限公司 | 2024-10-11 | — | — | CN | claimed |
| CN-118393788-A | Ion conducting layer for electrochromic device, preparation method of ion conducting layer, electrochromic device and application of ion conducting layer | 比亚迪股份有限公司 | 2024-07-26 | — | — | CN | claimed |
| CN-118393788-B | Ion conducting layer for electrochromic device, preparation method of ion conducting layer, electrochromic device and application of ion conducting layer | 比亚迪股份有限公司 | 2024-10-11 | — | — | CN | disclosed |
| CN-118393789-B | Ion balance layer for electrochromic device, preparation method of ion balance layer, electrochromic device and application of ion balance layer | 比亚迪股份有限公司 | 2024-10-11 | — | — | CN | disclosed |
| CN-118393789-A | Ion balance layer for electrochromic device, preparation method of ion balance layer, electrochromic device and application of ion balance layer | 比亚迪股份有限公司 | 2024-07-26 | — | — | CN | disclosed |
| CN-118393788-A | Ion conducting layer for electrochromic device, preparation method of ion conducting layer, electrochromic device and application of ion conducting layer | 比亚迪股份有限公司 | 2024-07-26 | — | — | CN | disclosed |