Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetracycline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | USP2 | O75604 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | POLB | P06746 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | RECQL | P46063 | 2/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | THRB | P10828 | 4/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.67 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetracycline SCHEMBL12856676 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL4368808 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL13782457 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL13782538 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL6055760 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL3098 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL1404253 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL12247641 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL21900130 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Epitetracycline SCHEMBL19771301 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 338349 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118767950-B | Bismuth composite material and preparation method and application thereof | 中铝科学技术研究院有限公司 | 2025-01-07 | — | — | CN | claimed |
| CN-119258984-A | Preparation method and application of magnetic rectorite/water bloom algae mud/river and lake sediment composite biochar material | 武汉大学 | 2025-01-07 | — | — | CN | claimed |
| CN-119269688-A | Method for determining residual quantity of penicillin and tetracycline antibiotics in citrus products | 南宁海关技术中心 | 2025-01-07 | — | — | CN | claimed |
| CN-119236902-A | Graphene oxide composite filter membrane and preparation method and application thereof | 武汉理工大学三亚科教创新园 | 2025-01-03 | — | — | CN | claimed |
| CN-119237014-A | Hydrogel catalytic membrane containing diatomic sites and limited-area water purification application | 天津工业大学 | 2025-01-03 | — | — | CN | claimed |
| US-12180511-B2 | Automated production of viral vectors | LONZA WALKERSVILLE, INC (US) | 2024-12-31 | — | — | US | claimed |
| US-12171790-B2 | Microorganisms engineered to reduce hyperphenylalaninemia | SYNLOGIC OPERATING COMPANY, INC. (US) | 2024-12-24 | — | — | US | claimed |
| CN-119143234-A | Construction method of acousto-optic catalytic reactor for removing tetracycline by using photoactive MOF | 江苏第二师范学院 | 2024-12-17 | — | — | CN | claimed |
| CN-116444276-B | High-entropy boride ceramic nano powder and preparation method and application thereof | 华南理工大学 | 2024-12-17 | — | — | CN | claimed |
| CN-117137884-B | Nanometer medicinal composition based on bacterial cell membrane, and preparation method and application thereof | 苏州大学 | 2024-12-13 | — | — | CN | claimed |
| US-3962414-A | Structured bioerodible drug delivery device | ALZA CORPORATION (US) | 1976-06-08 | — | — | US | claimed |
| US-3960757-A | HYDROPHOBIC | TOYO JOZO CO., LTD. (JA) | 1976-06-01 | — | — | US | claimed |
| US-3957983-A | ANTIBIOTICS | INTELLECTUAL PROPERTY DEVELOPMENT CORPORATION (US) | 1976-05-18 | — | — | US | claimed |
| US-3954862-A | RHODIUM CATALYZED HYDROGENATION | PFIZER INC. (US) | 1976-05-04 | — | — | US | claimed |
| US-3951962-A | ANTIBACTERIAL | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JA) | 1976-04-20 | — | — | US | claimed |
| US-3952099-A | MICROBIOCIDE, SUGAR ESTER, SULFOXIDE | THE PROCTER & GAMBLE COMPANY (US) | 1976-04-20 | — | — | US | claimed |
| US-3947517-A | Stereoselective introduction of tetracyclines hydroxyl group at 12(a) position in synthesis of tetracyclines | RESEARCH CORPORATION (US) | 1976-03-30 | — | — | US | claimed |
| US-3944668-A | TETRACYCLINE AND 5-CHLORO- OR 5,7-DICHLORO-8-HYDROXY QUINOLINE | PATERSON ZOCHONIS & COMPANY, LIMITED (EN) | 1976-03-16 | — | — | US | claimed |
| US-3939831-A | Process for preparing medicinal dressings | INTREPRINDEREA FLACARA ROSIE (RU) | 1976-02-24 | — | — | US | claimed |
| US-3932615-A | Process for the preparation of granules | MEIJI SEIKA CO., LTD. (JA) | 1976-01-13 | — | — | US | claimed |