Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetracycline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | USP2 | O75604 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | POLB | P06746 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | RECQL | P46063 | 2/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | THRB | P10828 | 4/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.67 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetracycline SCHEMBL12856676 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL13782457 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL3099 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL13782538 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL6055760 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL3098 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL1404253 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL12247641 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL21900130 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Epitetracycline SCHEMBL19771301 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113354057-B | Degradation treatment method for copper complexing reinforced tetracycline pollutants | 同济大学 | 2023-02-10 | — | — | CN | claimed |
| CN-113354057-A | Degradation treatment method for copper complexing reinforced tetracycline pollutants | 同济大学 | 2021-09-07 | — | — | CN | claimed |
| CN-1726290-A | Method for producing genetically modified organisms for screening active substances | AVENTIS PHARMA GMBH (DE) | 2006-01-25 | — | — | CN | claimed |
| US-20040143854-A1 | Method for generating a genetically modified organism | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-07-22 | — | — | US | claimed |
| CN-113354057-B | Degradation treatment method for copper complexing reinforced tetracycline pollutants | 同济大学 | 2023-02-10 | — | — | CN | disclosed |
| CN-113354057-B | Degradation treatment method for copper complexing reinforced tetracycline pollutants | 同济大学 | 2023-02-10 | — | — | CN | disclosed |
| CN-113354057-A | Degradation treatment method for copper complexing reinforced tetracycline pollutants | 同济大学 | 2021-09-07 | — | — | CN | disclosed |
| CN-113354057-A | Degradation treatment method for copper complexing reinforced tetracycline pollutants | 同济大学 | 2021-09-07 | — | — | CN | disclosed |
| EP-1454140-B1 | DIAGNOSIS AND TREATMENT OF ATHEROSCLEROSIS | CAMBRIDGE THERANOSTICS LTD (GB) | 2009-07-08 | — | — | EP | disclosed |