Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 20/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | HCK | P08631 | 1/20 | 0.58 |
| ▸ | FGR | P09769 | 1/20 | 0.58 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.58 |
| ▸ | FLT4 | P35916 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.58 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.58 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30990443 | 0.86 | RET (0.64) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL31639650 | 0.84 | RET (0.98) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL18518276 | 0.83 | RET (1.00) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL31639968 | 0.83 | RET (0.82) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL18518835 | 0.83 | RET (1.00) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL30990442 | 0.81 | RET (0.49) | RETHCKRPS6KB1FLT4KDR | |
| SCHEMBL30990436 | 0.78 | RET (0.54) | RETKDR | |
| SCHEMBL18518591 | 0.77 | RET (1.00) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL31639590 | 0.76 | RET (0.73) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL31639866 | 0.74 | RET (0.69) | RETCYP1A2HCKFGRRPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665720-A2 | ISOINDOLINONE GLUTARIMIDE AND PHENYL GLUTARIMIDE ANALOGS AS DEGRADERS OF RET KINASE | Bristol-Myers Squibb Company (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024173832-A2 | ISOINDOLINONE GLUTARIMIDE AND PHENYL GLUTARIMIDE ANALOGS AS DEGRADERS OF RET KINASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-08-22 | — | — | WO | disclosed |