Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 16/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30990430 | 0.90 | RET (0.53) | RETEGFRBTK | |
| SCHEMBL30990450 | 0.88 | RET (0.51) | RETEGFRBTKKDR | |
| SCHEMBL30990426 | 0.88 | RET (0.51) | RETEGFRBTK | |
| SCHEMBL30990441 | 0.84 | RET (0.46) | RETEGFRBTKKDR | |
| SCHEMBL30990442 | 0.83 | RET (0.49) | RETLCKSRCTEKEGFR | |
| SCHEMBL30990471 | 0.83 | RET (0.53) | RETLCKSRCTEKBTK | |
| SCHEMBL30990486 | 0.83 | RET (0.53) | RETLCKSRCTEKBTK | |
| SCHEMBL30990418 | 0.82 | RET (0.54) | RETSRCEGFRKDR | |
| SCHEMBL30990449 | 0.82 | RET (0.54) | RETSRCEGFRKDR | |
| SCHEMBL30990455 | 0.79 | RET (0.53) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665720-A2 | ISOINDOLINONE GLUTARIMIDE AND PHENYL GLUTARIMIDE ANALOGS AS DEGRADERS OF RET KINASE | Bristol-Myers Squibb Company (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024173832-A2 | ISOINDOLINONE GLUTARIMIDE AND PHENYL GLUTARIMIDE ANALOGS AS DEGRADERS OF RET KINASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-08-22 | — | — | WO | disclosed |