SCHEMBL30993448

SCHEMBL30993448

NCC#Cc1cccc(C(=O)NC2CCC(=O)NC2=O)c1F

nearest known ligand 0.67

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 20/20 0.67
BRD4 O60885 2/20 0.50
DDB1 Q16531 3/20 0.49
IKZF3 Q9UKT9 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30993626 0.92 CRBN (0.64) CRBNBRD4DDB1IKZF3
SCHEMBL31248977 0.81 CRBN (0.51) CRBNDDB1
SCHEMBL30993589 0.80 CRBN (0.55) CRBNBRD4DDB1IKZF3
SCHEMBL30993053 0.80 CRBN (0.67) CRBNBRD4DDB1IKZF3
SCHEMBL30993936 0.78 CRBN (0.68) CRBNBRD4DDB1IKZF3
SCHEMBL31746429 0.78 CRBN (0.74) CRBNBRD4DDB1IKZF3
SCHEMBL26972237 0.78 CRBN (0.74) CRBNBRD4DDB1IKZF3
SCHEMBL31746535 0.78 CRBN (0.74) CRBNBRD4DDB1IKZF3
SCHEMBL30993686 0.78 CRBN (0.67) CRBNBRD4DDB1IKZF3
SCHEMBL30993117 0.76 CRBN (0.56) CRBNBRD4DDB1IKZF3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024130095-A1 COMPOUNDS AND COMPOSITIONS AS CBP/P300 DEGRADERS AND USES THEREOF REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2024-06-20 WO disclosed