Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | F13A1 | P00488 | 1/20 | 0.50 |
| ▸ | TGM2 | P21980 | 1/20 | 0.50 |
| ▸ | TGM1 | P22735 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31288410 | 1.00 | JAK2 (0.53) | JAK2JAK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6095209 | 1.00 | JAK2 (0.53) | JAK2JAK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL30960033 | 0.93 | JAK2 (0.61) | JAK2JAK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL30959962 | 0.93 | JAK2 (0.61) | JAK2JAK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7195745 | 0.93 | HTR2C (0.54) | JAK2JAK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL24025369 | 0.93 | GPR119 (0.61) | JAK2JAK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL30960004 | 0.93 | JAK2 (0.61) | JAK2JAK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL17112637 | 0.91 | SMN1; SMN2 (0.60) | JAK2JAK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL17112639 | 0.91 | SMN1; SMN2 (0.60) | JAK2JAK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL30289643 | 0.90 | SMN1; SMN2 (0.50) | JAK2JAK1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024130095-A1 | COMPOUNDS AND COMPOSITIONS AS CBP/P300 DEGRADERS AND USES THEREOF | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-06-20 | — | — | WO | disclosed |