Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 9/20 | 0.41 |
| ▸ | HTR1A | P08908 | 8/20 | 0.41 |
| ▸ | HTR2B | P41595 | 8/20 | 0.41 |
| ▸ | HTR5A | P47898 | 8/20 | 0.41 |
| ▸ | HTR1D | P28221 | 7/20 | 0.41 |
| ▸ | HTR1B | P28222 | 7/20 | 0.41 |
| ▸ | HTR2A | P28223 | 7/20 | 0.41 |
| ▸ | HTR6 | P50406 | 7/20 | 0.41 |
| ▸ | HTR1E | P28566 | 6/20 | 0.41 |
| ▸ | HTR3A | P46098 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29375643 | 0.84 | HTR1A (0.37) | HTR7HTR1AHTR2BHTR5AHTR1D | |
| SCHEMBL31680193 | 0.84 | MAP2 (0.34) | HTR7HTR1AHTR2BHTR5AHTR1D | |
| SCHEMBL31669654 | 0.83 | HTR1A (0.36) | HTR7HTR1AHTR2BHTR5AHTR1D | |
| SCHEMBL21331833 | 0.79 | HTR1A (0.41) | HTR7HTR1AHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL21331777 | 0.79 | SMN1; SMN2 (0.43) | HTR7HTR1AHTR2BHTR5AHTR1D | |
| SCHEMBL29841836 | 0.79 | HPGD (0.40) | HPGDRAB9ASMN1; SMN2NPC1TSHR | |
| SCHEMBL3023273 | 0.79 | HPGD (0.40) | HPGDRAB9ASMN1; SMN2NPC1TSHR | |
| SCHEMBL2709792 | 0.78 | HPGD (0.42) | HTR7HTR1AHTR2BHTR5AHTR1D | |
| SCHEMBL17513073 | 0.78 | HPGD (0.38) | HPGDRAB9ASMN1; SMN2NPC1TSHR | |
| SCHEMBL28353796 | 0.77 | HPGD (0.40) | HPGDRAB9ASMN1; SMN2NPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240246968-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12C MUTANT | MERCK SHARP & DOHME LLC | 2024-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240246968-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12C MUTANT | KRAS, NRAS, HRAS | HTR7 4842/4885HTR1A 4840/4885HTR2B 4845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.