Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.80 |
| ▸ | MAPT | P10636 | 4/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.80 |
| ▸ | NPC1 | O15118 | 1/20 | 0.80 |
| ▸ | RAB9A | P51151 | 1/20 | 0.80 |
| ▸ | HPGD | P15428 | 6/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | GAA | P10253 | 4/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3869652 | 0.89 | KDM4E (1.00) | KDM4EALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL27478028 | 0.87 | ALDH1A1 (0.62) | KDM4EALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL9518758 | 0.79 | KDM4E (0.56) | KDM4EALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL9518821 | 0.79 | ALDH1A1 (0.65) | KDM4EALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL2807005 | 0.79 | ALDH1A1 (0.56) | KDM4EALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL30997272 | 0.79 | KDM4E (0.57) | KDM4EALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL3597471 | 0.77 | KDM4E (0.55) | KDM4EALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL1435638 | 0.76 | HRH3 (0.53) | KDM4EALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL28160835 | 0.76 | KDM4E (0.54) | KDM4EALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL30997246 | 0.75 | KDM4E (0.53) | KDM4EALDH1A1MAPTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4471034-A1 | DISUBSTITUTED OCTAHYDROPYRROLO[3,4-C]PYRROLE METHYL KETONE DERIVATIVE AND APPLICATION THEREOF | Jiangsu NHWA Pharmaceutical Co., Ltd (CN) | 2024-12-04 | — | — | EP | disclosed |
| CN-118556061-A | Disubstituted octahydropyrrolo [3,4-c ] pyrrole methyl ketone derivative and application thereof | 江苏恩华药业股份有限公司 | 2024-08-27 | — | — | CN | disclosed |