Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CGAS | Q8N884 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | S100B | P04271 | 1/20 | 0.32 |
| ▸ | PRNP | P04156 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.30 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30039683 | 0.74 | CYP17A1 (0.34) | ALDH1A1P2RX7 | |
| SCHEMBL30038679 | 0.68 | HSP90AA1 (0.34) | L3MBTL1ALDH1A1PRNPSRCAMY1A | |
| SCHEMBL24638023 | 0.66 | KDM4E (0.46) | L3MBTL1ALDH1A1S100BMEN1GAA | |
| SCHEMBL23702268 | 0.65 | MEN1 (0.43) | L3MBTL1ALDH1A1PRNPSRCMEN1 | |
| SCHEMBL2270840 | 0.63 | FGFR1 (0.56) | L3MBTL1ALDH1A1PRNPSRCMEN1 | |
| SCHEMBL26655062 | 0.62 | FGFR1 (0.43) | L3MBTL1ALDH1A1PRNPSRCMEN1 | |
| SCHEMBL34475643 | 0.62 | NQO2 (0.41) | L3MBTL1ALDH1A1PRNPMEN1POLB | |
| SCHEMBL24529684 | 0.62 | NQO2 (0.41) | L3MBTL1ALDH1A1PRNPMEN1POLB | |
| SCHEMBL9678363 | 0.60 | TUBB1 (0.40) | L3MBTL1AMY1APOLB | |
| SCHEMBL22323913 | 0.58 | HDAC6 (0.48) | L3MBTL1ALDH1A1SRCMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240246968-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12C MUTANT | MERCK SHARP & DOHME LLC | 2024-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240246968-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12C MUTANT | KRAS, NRAS, HRAS | CGAS 1910/4885L3MBTL1 3744/4885ALDH1A1 3065/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.