Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31000311 | 0.88 | CDK4 (0.45) | CDK4CCND1CCND3CDK6CDK2 | |
| SCHEMBL31000233 | 0.88 | CDK4 (0.45) | CDK4CCND1CCND3CDK6CDK2 | |
| SCHEMBL31000072 | 0.88 | CDK4 (0.45) | CDK4CCND1CCND3CDK6CDK2 | |
| SCHEMBL31000209 | 0.86 | CDK4 (0.43) | CDK4CCND1CCND3CDK6CDK2 | |
| SCHEMBL31000174 | 0.85 | CDK4 (0.44) | CDK4CCND1CCND3CDK6CDK2 | |
| SCHEMBL31000104 | 0.81 | IGF1R (0.40) | CDK4CCND1CCND3CDK6CDK2 | |
| SCHEMBL31000192 | 0.79 | CDK4 (0.42) | CDK4CCND1CCND3CDK6CDK2 | |
| SCHEMBL31639355 | 0.77 | DNMT3A (0.34) | CDK4CCND1CCND3CDK6ALK | |
| SCHEMBL31000279 | 0.77 | FYN (0.35) | CDK2IGF1R | |
| SCHEMBL31000100 | 0.76 | IGF1R (0.39) | CDK4CCND1CCND3CDK6CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658659-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | Children's Hospital Medical Center (US) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024163764-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2024-08-08 | — | — | WO | disclosed |