Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 7/20 | 0.38 |
| ▸ | NRAS | P01111 | 6/20 | 0.38 |
| ▸ | CDK2 | P24941 | 4/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 4/20 | 0.36 |
| ▸ | CCNH | P51946 | 4/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.36 |
| ▸ | CCNK | O75909 | 3/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.36 |
| ▸ | CDK9 | P50750 | 3/20 | 0.36 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.36 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | BCL6 | P41182 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31000172 | 0.85 | FLT3 (0.37) | FLT3NRASCDK2IGF1RCDK7 | |
| SCHEMBL31000198 | 0.83 | CDK7 (0.41) | FLT3NRASCDK2IGF1RCDK7 | |
| SCHEMBL31000192 | 0.83 | CDK4 (0.42) | CDK2IGF1RALK | |
| SCHEMBL31000306 | 0.83 | GAA (0.40) | FLT3NRASCDK2IGF1RCDK7 | |
| SCHEMBL31000215 | 0.81 | FLT3 (0.39) | FLT3NRASCDK2IGF1RCDK7 | |
| SCHEMBL31000224 | 0.81 | FLT3 (0.39) | FLT3NRASCDK2IGF1RCDK7 | |
| SCHEMBL31000232 | 0.81 | FLT3 (0.39) | FLT3NRASCDK2IGF1RCDK7 | |
| SCHEMBL31000190 | 0.80 | FLT3 (0.39) | FLT3NRASCDK2IGF1RCDK7 | |
| SCHEMBL31639195 | 0.79 | FLT3 (0.46) | FLT3NRASCDK7CCNHIRAK1 | |
| SCHEMBL31000079 | 0.78 | PIM1 (0.35) | CDK2IGF1RCCNT1CDK9TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658659-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | Children's Hospital Medical Center (US) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024163764-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2024-08-08 | — | — | WO | disclosed |