Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.37 |
| ▸ | IGF1R | P08069 | 6/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 3/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | NRAS | P01111 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31000146 | 0.83 | FLT3 (0.38) | IGF1RCDK2CCNT1CDK9NRAS | |
| SCHEMBL31639195 | 0.82 | FLT3 (0.46) | GAAMTORPIK3CALRRK2NRAS | |
| SCHEMBL31000188 | 0.82 | PIK3CA (0.40) | GAAIGF1RCDK2PIK3CACCNT1 | |
| SCHEMBL31000187 | 0.82 | PIK3CA (0.40) | GAAIGF1RCDK2PIK3CACCNT1 | |
| SCHEMBL31639610 | 0.79 | NRAS (0.39) | LRRK2NRASFLT3FYN | |
| SCHEMBL31000250 | 0.79 | GAA (0.41) | GAANPC1RAB9ASMN1; SMN2MTOR | |
| SCHEMBL31000172 | 0.78 | FLT3 (0.37) | IGF1RCDK2CCNT1CDK9LRRK2 | |
| SCHEMBL31000232 | 0.78 | FLT3 (0.39) | KCNH2IGF1RCDK2CCNT1CDK9 | |
| SCHEMBL31000198 | 0.77 | CDK7 (0.41) | KCNH2IGF1RCDK2CCNT1CDK9 | |
| SCHEMBL31639125 | 0.75 | MTOR (0.40) | GAANPC1RAB9ASMN1; SMN2MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658659-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | Children's Hospital Medical Center (US) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024163764-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2024-08-08 | — | — | WO | disclosed |