Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11414250 | 0.80 | HCAR2 (0.53) | HCAR2CYP1A2HCAR3DRD2SIGMAR1 | |
| SCHEMBL3100973 | 0.73 | HCAR2 (1.00) | HCAR2CYP1A2HCAR3 | |
| SCHEMBL3101214 | 0.71 | HCAR2 (0.56) | HCAR2CYP1A2HCAR3DRD2SIGMAR1 | |
| SCHEMBL5531839 | 0.70 | HCAR2 (0.57) | HCAR2CYP1A2HCAR3DRD2SIGMAR1 | |
| SCHEMBL3100362 | 0.69 | HCAR2 (0.43) | HCAR2CYP1A2HCAR3HTTDRD2 | |
| SCHEMBL15621142 | 0.68 | HCAR2 (0.51) | HCAR2HSD17B10SMN1; SMN2HTTKIF11 | |
| SCHEMBL3821094 | 0.67 | HCAR2 (0.67) | HCAR2CYP1A2HCAR3HSD17B10ALDH1A1 | |
| SCHEMBL5521792 | 0.67 | HCAR2 (0.51) | HCAR2CYP1A2HCAR3SMN1; SMN2DRD2 | |
| SCHEMBL5520638 | 0.67 | HCAR2 (0.40) | HCAR2CYP1A2HCAR3TSHRDRD2 | |
| SCHEMBL5522029 | 0.67 | HCAR2 (0.41) | HCAR2CYP1A2HCAR3BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803837-B2 | 4-oxo-4,5-dihydro-furan-2-carboxylic acid derivatives and methods of treatment of metabolic-related disorders thereof | ARENA PHARMACEUTICALS, INC. (US) | 2010-09-28 | — | — | US | disclosed |
| US-20070161701-A1 | 4-oxo-4,5-dihydro-furan-2-carboxylic acid derivatives and methods of treatment of metabolic-related disorders thereof | ARENA PHARMACEUTICALS, INC. | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161701-A1 | 4-oxo-4,5-dihydro-furan-2-carboxylic acid derivatives and methods of treatment of metabolic-related disorders thereof | ABAT, G6PD, GLS2 | HCAR2 229/4885CYP1A2 172/4885HCAR3 373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.